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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(RARE-Hspa1b/lacZ)12Jrt
transgene insertion 12, Janet Rossant
MGI:3625954
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rdh10tm1c(KOMP)Wtsi/Rdh10tm1c(KOMP)Wtsi
Tg(Amh-cre)8815Reb/0
Tg(RARE-Hspa1b/lacZ)12Jrt/0
Tg(Stra8-icre)1Reb/0 		involves: C57BL/6 * C57BL/6N * CD-1 * FVB/N * SJL MGI:5475537
cn2
 		Rdh7tm1c(KOMP)Wtsi/Rdh7tm1c(KOMP)Wtsi
Tg(RARE-Hspa1b/lacZ)12Jrt/0
Tg(Vil1-cre)997Gum/0 		involves: C57BL/6J * C57BL/6N * CD-1 * SJL MGI:6362927
cx3
 		Dhrs3tm1Lex/Dhrs3tm1Lex
Tg(RARE-Hspa1b/lacZ)12Jrt/0 		involves: 129S5/SvEvBrd * C57BL/6 * CD-1 MGI:5553307


Genotype
MGI:5475537
cn1
Allelic
Composition		 Rdh10tm1c(KOMP)Wtsi/Rdh10tm1c(KOMP)Wtsi
Tg(Amh-cre)8815Reb/0
Tg(RARE-Hspa1b/lacZ)12Jrt/0
Tg(Stra8-icre)1Reb/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * CD-1 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rdh10tm1c(KOMP)Wtsi mutation (0 available); any Rdh10 mutation (20 available)
Tg(Amh-cre)8815Reb mutation (2 available)
Tg(RARE-Hspa1b/lacZ)12Jrt mutation (2 available)
Tg(Stra8-icre)1Reb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system

endocrine/exocrine glands




Genotype
MGI:6362927
cn2
Allelic
Composition		 Rdh7tm1c(KOMP)Wtsi/Rdh7tm1c(KOMP)Wtsi
Tg(RARE-Hspa1b/lacZ)12Jrt/0
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: C57BL/6J * C57BL/6N * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rdh7tm1c(KOMP)Wtsi mutation (0 available); any Rdh7 mutation (23 available)
Tg(RARE-Hspa1b/lacZ)12Jrt mutation (2 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:279231 )
N
• mice exhibit normal numbers of TH17 and T regulatory cells in the small intestine and colon
decreased lymphocyte cell number ( J:279231 )
• reduced NCR+ IL22-producing RORgammat+ innate lymphoid cells (ILC3s) in the small intestinal lamina propria
• however, the number of NCR- ILC3s and lymphoid tissue inducer (LTi) cells are normal
decreased susceptibility to bacterial infection ( J:279231 )
• enhanced resistance to colonization by gut pathogens (C. rodentium and S. Typhimurium) with reduced colony forming units in the feces and spleen
• however, IL22 supplementation reverses resistance

hematopoietic system
decreased lymphocyte cell number ( J:279231 )
• reduced NCR+ IL22-producing RORgammat+ innate lymphoid cells (ILC3s) in the small intestinal lamina propria
• however, the number of NCR- ILC3s and lymphoid tissue inducer (LTi) cells are normal




Genotype
MGI:5553307
cx3
Allelic
Composition		 Dhrs3tm1Lex/Dhrs3tm1Lex
Tg(RARE-Hspa1b/lacZ)12Jrt/0
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dhrs3tm1Lex mutation (3 available); any Dhrs3 mutation (25 available)
Tg(RARE-Hspa1b/lacZ)12Jrt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal embryo development ( J:203823 )
• mice exhibit severe developmental abnormalities with increased in transgene activity




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory