Phenotypes associated with this allele

• Allele Symbol: Nnt^C57BL/6J
• Allele Name: C57BL/6J
• Allele ID: MGI:3626282
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nnt^C57BL/6J/Nnt^C57BL/6J	C57BL/6J	MGI:3702942

Genotype
MGI:3702942

hm1

• Allelic Composition: Nnt^C57BL/6J/Nnt^C57BL/6J
• Genetic Background: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

disorganized adrenal gland zona fasciculata ( J:185986 )

• 3 month old adrenal glands show slightly disorganized zonae fasciculata than wild-type C57BL/6NHsd mice

abnormal adrenocortical cell morphology ( J:185986 )

• mice show higher levels of adrenocortical cell apoptosis than wild-type C57BL/6NHsd mice

decreased insulin secretion ( J:109356 )

• this phenotype is rescued by transgenic expression of full-length Nnt sequence derived from 129S6/SvEvTac

homeostasis/metabolism

decreased insulin secretion ( J:109356 )

• this phenotype is rescued by transgenic expression of full-length Nnt sequence derived from 129S6/SvEvTac

decreased circulating corticosterone level ( J:185986 )

• mice show lower basal and ACTH-stimulated levels of corticosterone than wild-type C57BL/6NHsd mice

impaired glucose tolerance ( J:109356 )

• this phenotype is rescued by transgenic expression of full-length Nnt sequence derived from 129S6/SvEvTac