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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tlr4lps-2J
defective lipopolysaccharide response 2 Jackson
MGI:3626283
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tlr4lps-2J/Tlr4lps-2J BXD29-Tlr4lps-2J/J MGI:3629222
ht2
 		Tlr4tm1Aki/Tlr4lps-2J involves: 129P2/OlaHsd * C57BL/6 * DBA/2J MGI:3629223


Genotype
MGI:3629222
hm1
Allelic
Composition		 Tlr4lps-2J/Tlr4lps-2J
Genetic
Background		 BXD29-Tlr4lps-2J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr4lps-2J mutation (0 available); any Tlr4 mutation (91 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal inflammatory response ( J:107391 )
• in response to inhaled LPS, mice are unresponsive without increases in Tnfa and PMNs like other BXD RI strains




Genotype
MGI:3629223
ht2
Allelic
Composition		 Tlr4tm1Aki/Tlr4lps-2J
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr4lps-2J mutation (0 available); any Tlr4 mutation (91 available)
Tlr4tm1Aki mutation (7 available); any Tlr4 mutation (91 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal inflammatory response ( J:107391 )
• in response to inhaled LPS, mice respond indistinguishably from Tlr4-deficient mice (no response)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory