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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Igk-Jtm1Dim
targeted mutation 1, Diane Mathis
MGI:3626300
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Igh-Jtm1Dim/Igh-J+
Igk-Jtm1Dim/Igk-J+
involves: 129S4/SvJae * C57BL/6 MGI:3640188


Genotype
MGI:3640188
cx1
Allelic
Composition
Igh-Jtm1Dim/Igh-J+
Igk-Jtm1Dim/Igk-J+
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Dim mutation (1 available); any Igh-J mutation (13 available)
Igk-Jtm1Dim mutation (1 available); any Igk-J mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the bone marrow contains an increase in the proportion of immature B cells and decrease in the proportion of mature B cells probably as the result of removal of cells expressing high-affinity anti-glucose-6-phosphate specificities during maturation
• detectable levels of anti-glucose-6-phosphate IgG unlike in wild-type mice
• 3- to 10-fold increase in the anti-glucose-6-phosphate IgM titer

hematopoietic system
• the bone marrow contains an increase in the proportion of immature B cells and decrease in the proportion of mature B cells probably as the result of removal of cells expressing high-affinity anti-glucose-6-phosphate specificities during maturation
• detectable levels of anti-glucose-6-phosphate IgG unlike in wild-type mice
• 3- to 10-fold increase in the anti-glucose-6-phosphate IgM titer





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory