Phenotypes associated with this allele

• Allele Symbol: Igh-J^tm1Dim
• Allele Name: targeted mutation 1, Diane Mathis
• Allele ID: MGI:3626301
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Igh-J^tm1Dim/Igh-J^+ Igk-J^tm1Dim/Igk-J^+	involves: 129S4/SvJae * C57BL/6	MGI:3640188

Genotype
MGI:3640188

cx1

• Allelic Composition: Igh-J^tm1Dim/Igh-J⁺; Igk-J^tm1Dim/Igk-J⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell differentiation ( J:107241 )

• the bone marrow contains an increase in the proportion of immature B cells and decrease in the proportion of mature B cells probably as the result of removal of cells expressing high-affinity anti-glucose-6-phosphate specificities during maturation

increased IgG level ( J:107241 )

• detectable levels of anti-glucose-6-phosphate IgG unlike in wild-type mice

increased IgM level ( J:107241 )

• 3- to 10-fold increase in the anti-glucose-6-phosphate IgM titer

hematopoietic system

abnormal B cell differentiation ( J:107241 )

• the bone marrow contains an increase in the proportion of immature B cells and decrease in the proportion of mature B cells probably as the result of removal of cells expressing high-affinity anti-glucose-6-phosphate specificities during maturation

increased IgG level ( J:107241 )

• detectable levels of anti-glucose-6-phosphate IgG unlike in wild-type mice

increased IgM level ( J:107241 )

• 3- to 10-fold increase in the anti-glucose-6-phosphate IgM titer