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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dclk1tm1Caw
targeted mutation 1, Christopher A Walsh
MGI:3626361
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dclk1tm1Caw/Dclk1tm1Caw involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J MGI:3628588
cx2
 		Dclk1tm1Caw/Dclk1tm1Caw
Dcxtm1Caw/Y 		involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J MGI:3628582
cx3
 		Dclk1tm1Caw/Dclk1tm1Caw
Dcxtm1Caw/Dcx+ 		involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J MGI:3628584
cx4
 		Dclk1tm1Caw/Dclk1+
Dcxtm1Caw/Dcx+ 		involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J MGI:3628593
cx5
 		Dclk1tm1Caw/Dclk1+
Dcxtm1Caw/Y 		involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J MGI:3628602


Genotype
MGI:3628588
hm1
Allelic
Composition		 Dclk1tm1Caw/Dclk1tm1Caw
Genetic
Background		 involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1Caw mutation (0 available); any Dclk1 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron morphology ( J:105301 )
• cortical neurons from Dcamkl1-null embryos transfected with Dcx RNAi show aberrant processes; dendritic processes appear shorter and more numerous than control Dcamkl1-deficient neurons and many cells appear to lack a primary dendrite
abnormal axon morphology ( J:105301 )
• cortical neurons from Dcamkl1-null embryos transfected with Dcx RNAi have much shorter axons than wild-type neurons transfected with Dcx RNAi (230 microns vs 702 microns)




Genotype
MGI:3628582
cx2
Allelic
Composition		 Dclk1tm1Caw/Dclk1tm1Caw
Dcxtm1Caw/Y
Genetic
Background		 involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1Caw mutation (0 available); any Dclk1 mutation (55 available)
Dcxtm1Caw mutation (0 available); any Dcx mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:105301 )
• more than 75% of double knockouts die within 2 days of birth

nervous system
abnormal brain morphology ( J:105301 )
• double knockouts exhibit disruption of most or all major axon tracts in the brain; brains of double knockouts display severely disorganized white-matter tracts
abnormal cerebellar foliation ( J:105301 )
• cerebellum of mutants has defective foliation; folia are severely hypoplastic, particularly on the ventral surface of the cerebellum
abnormal corpus callosum morphology ( J:105301 )
• there are no fibers crossing the midline of the corpus callosum; most axons end before reaching the midline and do not cross to the other side
• axons appear as multiple single axons with random orientation and without clear fasciculation rather than bundles
decreased corpus callosum size ( J:105301 )
• in mutants, corpus callosum is present at rostral levels but does not extend as far caudally as in wild-type mice; anterior portion is greatly reduced in thickness
abnormal hippocampal commissure morphology ( J:105301 )
• hippocampal commissures appear lumpy and disorganized
abnormal anterior commissure morphology ( J:105301 )
• aberrant anterior commissure bundles are observed
abnormal brain internal capsule morphology ( J:105301 )
• in some animals, internal capsule has abnormal morphology
absent brain internal capsule ( J:105301 )
• there is absence of an internal capsule in the striatum
abnormal brainstem morphology ( J:105301 )
• disruption of many brainstem nuclei is observed
abnormal striatum morphology ( J:105301 )
• there is absence of pencil fibers in the striatum
abnormal thalamus morphology ( J:105301 )
• disruption of many thalamic nuclei is observed
abnormal cerebral cortex morphology ( J:105301 )
• stratum pyramidale layer in pyramidal cell fields, CA3,CA2and CA1 is disorganized with multiple cell layers separated by irregular streams of white matter
abnormal stratification in cerebral cortex ( J:105301 )
• at P0, there is disruption of lamination of the cerebral cortex in the cingulate gyrus in double knockouts
thin cerebral cortex ( J:105301 )
• brains of double knockouts at P0 display a thin cerebral cortex
abnormal entorhinal cortex morphology ( J:105301 )
• no axons leave the region of the entorhinal cortex
abnormal hippocampus morphology ( J:105301 )
• subcortical white matter appears lumpy and disorganized
abnormal dentate gyrus morphology ( J:105301 )
• cells appear less tightly packed
abnormal hippocampus layer morphology ( J:105301 )
• there is markedly abnormal cell layering in the hippocampus
small cerebellum ( J:105301 )
• the cerebellum is small in double knockouts




Genotype
MGI:3628584
cx3
Allelic
Composition		 Dclk1tm1Caw/Dclk1tm1Caw
Dcxtm1Caw/Dcx+
Genetic
Background		 involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1Caw mutation (0 available); any Dclk1 mutation (55 available)
Dcxtm1Caw mutation (0 available); any Dcx mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reduced female fertility ( J:105301 )
• fertility appears to be reduced




Genotype
MGI:3628593
cx4
Allelic
Composition		 Dclk1tm1Caw/Dclk1+
Dcxtm1Caw/Dcx+
Genetic
Background		 involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1Caw mutation (0 available); any Dclk1 mutation (55 available)
Dcxtm1Caw mutation (0 available); any Dcx mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reduced female fertility ( J:105301 )
• fertility appears to be reduced




Genotype
MGI:3628602
cx5
Allelic
Composition		 Dclk1tm1Caw/Dclk1+
Dcxtm1Caw/Y
Genetic
Background		 involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1Caw mutation (0 available); any Dclk1 mutation (55 available)
Dcxtm1Caw mutation (0 available); any Dcx mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality ( J:105301 )
• a slightly lower proportion of Dcx-deficient, Dcamkl1-heterozygous males die postnatally than double knockouts

nervous system
abnormal brain morphology ( J:105301 )
• mutants have less severe and less penetrant white matter defects than double knockouts
enlarged lateral ventricles ( J:105301 )
• lateral ventricles are enlarged in mutants
absent corpus callosum ( J:105301 )
• some animals have an absent corpus callosum




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory