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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Capn2tm1Pag
targeted mutation 1, Peter A Greer
MGI:3628453
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Capn2tm1Pag/Capn2tm1Pag involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3628918
ht2
Capn2tm1Pag/Capn2+ involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3628919


Genotype
MGI:3628918
hm1
Allelic
Composition
Capn2tm1Pag/Capn2tm1Pag
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn2tm1Pag mutation (0 available); any Capn2 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no homozygous embryos are found between E10.5 and E18.5; only 2/90 embryos isolated at E2.5 to 3.5 were homozygous
• no embryos examined at the 8-cell (blastocyst) stage are homozygous

embryo




Genotype
MGI:3628919
ht2
Allelic
Composition
Capn2tm1Pag/Capn2+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn2tm1Pag mutation (0 available); any Capn2 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• ratio of heterozygotes to wild-type offspring heavily favors heterozygotes; instead of 1:2 expected hets to wild-type, 23 wild-type to 176 heterosygotes is observed
• when mutant allele is maternally-derived, overrepresentation of heterozygotes is more pronounced than when mutant allele is transmitted by the male





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory