All Phenotypes Ar<tm3(AR)Dmr> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Ar^tm3(AR)Dmr/Y Tg(TRAMP)8247Ng/0	involves: 129S1/Sv * C57BL/6	MGI:3629753
ot2	Ar^tm3(AR)Dmr/Y	involves: 129S1/Sv * C57BL/6J	MGI:3629745

Allelic Composition	Ar^tm3(AR)Dmr/Y Tg(TRAMP)8247Ng/0
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ar^tm3(AR)Dmr mutation (1 available); any Ar mutation (23 available)
Tg(TRAMP)8247Ng mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor incidence ( J:108849 )

• at 29 weeks of age, only 28% of transgenic mutant mice had a palpable tumor or had died due to prostate cancer, compared to wild-type transgenic mice: shorter Q tract length confers some protection from prostate cancer

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:108849

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased percent body fat/body weight ( J:108849 )

• 24-month old males showed a trend toward higher percentage of body fat relative to wild-type or Ar^tm1(AR)Dmr males

growth/size/body

growth/size/body region phenotype ( J:114552 )

N	• hemizygous mutant males are of normal size and body weight at 22-23 months of age

increased body weight ( J:108849 )

• hemizygous mutant males display a trend toward higher body weights than wild-type or Ar^tm1(AR)Dmr males

reproductive system

reproductive system phenotype ( J:104360 )

N	• hemizygous mutant males exhibit normal fertility and normal testes

behavior/neurological

behavior/neurological phenotype ( J:114552 )

N	• hemizygous mutant males display normal forelimb grip-strength with no evidence of neuromuscular weakness at 22-23 months of age

muscle

muscle phenotype ( J:114552 )

N	• at 3-5 months of age, hemizygous mutant males display normal skeletal muscle morphology, with no evidence of neurogenic atrophy or myopathy in hind-limb muscles

nervous system

nervous system phenotype ( J:114552 )

N	• aged hemizygous mutant males show normal spinal cord morphology

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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