Phenotypes associated with this allele

• Allele Symbol: Ptgs2^tm1Fun
• Allele Name: targeted mutation 1, Colin D Funk
• Allele ID: MGI:3628614
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptgs2^tm1Fun/Ptgs2^tm1Fun	involves: 129S6/SvEvTac * C57BL/6	MGI:3629783

Genotype
MGI:3629783

hm1

• Allelic Composition: Ptgs2^tm1Fun/Ptgs2^tm1Fun
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal blood coagulation ( J:108957 )

abnormal platelet physiology ( J:108957 )

• drop in circulating platelets after collagen injection is greater than normal

abnormal thrombolysis ( J:108957 )

decreased susceptibility to induced thrombosis ( J:108957 )

• carotid artery occlusion time after photochemical injury is extended

decreased prostaglandin level ( J:109548 )

• near absence of LPS induced synthesis

decreased urine prostaglandin level ( J:108957 )

• significantly reduced urinary excretion of 11alpha-hydroxy-9,15-dioxo-2,3,4,5-tetranor-prostane-1,20 dioic acid

• significantly reduced urinary excretion of 2,3-dinor-6keto-PGF1a

cardiovascular system

increased systemic arterial systolic blood pressure ( J:108957 )

• elevated systolic blood pressure at 3 months of age

renal/urinary system

decreased urine prostaglandin level ( J:108957 )

• significantly reduced urinary excretion of 11alpha-hydroxy-9,15-dioxo-2,3,4,5-tetranor-prostane-1,20 dioic acid

• significantly reduced urinary excretion of 2,3-dinor-6keto-PGF1a

hematopoietic system

abnormal platelet physiology ( J:108957 )

• drop in circulating platelets after collagen injection is greater than normal