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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cxcr4tm2Tng
targeted mutation 2, Takashi Nagasawa
MGI:3628644
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cxcr4tm1Tng/Cxcr4tm2Tng
Tg(Tek-cre)12Flv/0 		involves: 129P2/OlaHsd * C3H * C57BL/6 MGI:5502187
cn2
 		Cd19tm1(cre)Cgn/Cd19+
Cxcr4tm1Tng/Cxcr4tm2Tng 		involves: 129P2/OlaHsd * C57BL/6 MGI:3639683


Genotype
MGI:5502187
cn1
Allelic
Composition		 Cxcr4tm1Tng/Cxcr4tm2Tng
Tg(Tek-cre)12Flv/0
Genetic
Background		 involves: 129P2/OlaHsd * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr4tm1Tng mutation (1 available); any Cxcr4 mutation (46 available)
Cxcr4tm2Tng mutation (1 available); any Cxcr4 mutation (46 available)
Tg(Tek-cre)12Flv mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal skin vasculature morphology ( J:195048 )
• mice exhibit a failure of nerve-vessel alignment in developing limb skin compared with wild-type mice
• however, vascular density is normal
abnormal developmental vascular remodeling ( J:195048 )
• disorganized branching patterns in developing limb skin
abnormal vascular smooth muscle morphology ( J:195048 )
• reduced smooth muscle cell coverage of small diameter branched vessels
• however, coverage of large diameter veins is normal

nervous system
nervous system phenotype ( J:195048 )
N
• mice exhibit normal innervation accompanied by migrating Schwann cells

integument
abnormal skin vasculature morphology ( J:195048 )
• mice exhibit a failure of nerve-vessel alignment in developing limb skin compared with wild-type mice
• however, vascular density is normal

muscle
abnormal vascular smooth muscle morphology ( J:195048 )
• reduced smooth muscle cell coverage of small diameter branched vessels
• however, coverage of large diameter veins is normal




Genotype
MGI:3639683
cn2
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Cxcr4tm1Tng/Cxcr4tm2Tng
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Cxcr4tm1Tng mutation (1 available); any Cxcr4 mutation (46 available)
Cxcr4tm2Tng mutation (1 available); any Cxcr4 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased plasma cell number ( J:109147 )
• the number of plasma cells in bone marrow were severely reduced
• the numbers of mature B cells and plasma cells in spleen were normal

immune system
decreased plasma cell number ( J:109147 )
• the number of plasma cells in bone marrow were severely reduced
• the numbers of mature B cells and plasma cells in spleen were normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory