Analysis Tools
mortality/aging
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• die at E7.5 - E8.5
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Allele Symbol Allele Name Allele ID |
Abcb7tm1Mdf targeted mutation 1, Mark D Fleming MGI:3628654 |
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| Summary |
8 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• die at E7.5 - E8.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• pale, swollen mitochondria
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• mild hepatic architectural disarray and hepatocellular multinucleation are seen
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• many cytosolic lipid droplets and pale swollen mitochondria are seen suggesting metabolic or mitochondrial damage
• multinucleated hepatocytes are seen
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• pale, swollen mitochondria
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• 2-fold increase in serum levels of liver-derived transaminases indicative of liver damage
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• 76% increase in total liver iron; however, serum iron and total iron binding capacity are similar to controls and no signs of mitochondrial iron overload are detected
• a small subset of hepatocytes particularly cells adjacent to a portal triad or central vein, contain abundant, coarsely granular cytosolic iron deposits
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• 50% reduction in hepatic activity of xanthine oxidase; however no change in expression is detected
• about a 20% decrease in hepatic mitochondrial activity of succinate dehydrogenase when normalized to cytochrome C oxidase activity
• about a 90% and 60% decrease in cytosolic aconitate hydratase 1 (Aco1) activity and protein, respectivly, are seen in the liver
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• only 4.3% of pups rather than the expected 12.5% are found at P1
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• none are found at weaning
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N |
• no gross brain abnormalities are detected
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• die at or before E6.5 - E7.5; however no excessive iron deposition is seen
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• slightly growth retarded
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• hemorrhage and fibrin in the region of the ectoplacental cone
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• slightly growth retarded
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• around the ectoplacental cone
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• die at or before E6.5 - E7.5; however no excessive iron deposition is seen
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• slightly growth retarded
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• hemorrhage and fibrin in the region of the ectoplacental cone
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• slightly growth retarded
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• around the ectoplacental cone
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/05/2024 MGI 6.24 |
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