Phenotypes associated with this allele

• Allele Symbol: H2ⁱ⁵
• Allele Name: i5 variant
• Allele ID: MGI:3628763
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	H2^i5/H2^i5	NOD.Cg-H2^i5	MGI:3628774
ht2	H2^i5/H2^g7	NOD.Cg-H2^i5	MGI:3628789

Genotype
MGI:3628774

hm1

• Allelic Composition: H2ⁱ⁵/H2ⁱ⁵
• Genetic Background: NOD.Cg-H2ⁱ⁵

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:14178 )

• no female mice homozygous for this haplotype develop diabetes after cyclophosphamide injections during 5-13 months of observation

endocrine/exocrine glands

periinsulitis ( J:14178 )

• female mice display spontaneous perivascular and periductal lymphocytic infiltration by 5-7 months of age as do older mice (10-17 months of age); mice display perivascular and periductal infiltrates with or without cyclophosphamide treatment

immune system

periinsulitis ( J:14178 )

• female mice display spontaneous perivascular and periductal lymphocytic infiltration by 5-7 months of age as do older mice (10-17 months of age); mice display perivascular and periductal infiltrates with or without cyclophosphamide treatment

decreased susceptibility to autoimmune diabetes ( J:14178 )

• no female mice homozygous for the haplotype develop diabetes spontaneously during 5-13 months of observation

Genotype
MGI:3628789

ht2

• Allelic Composition: H2ⁱ⁵/H2^g7
• Genetic Background: NOD.Cg-H2ⁱ⁵

immune system

decreased susceptibility to autoimmune diabetes ( J:14178 )

• no females develop diabetes spontaneously over 5-7 months