About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		H2i7
i7 variant
MGI:3628766
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		H2i7/H2i7 NOD.Cg-H2i7 MGI:3628775
ht2
 		H2i7/H2g7 (NOD x NOD.Cg-H2i7)F1 MGI:3628793
ht3
 		H2i7/H2g7 NOD.Cg-H2i7 MGI:3628791


Genotype
MGI:3628775
hm1
Allelic
Composition		 H2i7/H2i7
Genetic
Background		 NOD.Cg-H2i7
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2i7 mutation (1 available); any H2 mutation (282 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
periinsulitis ( J:14178 )
• female mice display spontaneous perivascular and periductal lymphocytic infiltration by 9 months of age; mice between 10 and 12 months of age that are treated with cyclophospamide display perivascular and periductal infiltrates

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:14178 )
• no female mice homozygous for this haplotype develop diabetes after cyclophosphamide injections during 5-13 months of observation

immune system
periinsulitis ( J:14178 )
• female mice display spontaneous perivascular and periductal lymphocytic infiltration by 9 months of age; mice between 10 and 12 months of age that are treated with cyclophospamide display perivascular and periductal infiltrates
decreased susceptibility to autoimmune diabetes ( J:14178 )
• no female mice homozygous for the haplotype develop diabetes spontaneously during 5-13 months of observation




Genotype
MGI:3628793
ht2
Allelic
Composition		 H2i7/H2g7
Genetic
Background		 (NOD x NOD.Cg-H2i7)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (24 available); any H2 mutation (282 available)
H2i7 mutation (1 available); any H2 mutation (282 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
insulitis ( J:14178 )
• no female mice develop insulitis between 5-7 months of age; a small number of male mice do display mild insulitis

immune system
insulitis ( J:14178 )
• no female mice develop insulitis between 5-7 months of age; a small number of male mice do display mild insulitis




Genotype
MGI:3628791
ht3
Allelic
Composition		 H2i7/H2g7
Genetic
Background		 NOD.Cg-H2i7
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (24 available); any H2 mutation (282 available)
H2i7 mutation (1 available); any H2 mutation (282 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to autoimmune diabetes ( J:14178 )
• no females develop diabetes spontaneously over 5-7 months




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory