All Phenotypes Psmc3ip<tm1Rdco> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Psmc3ip^tm1Rdco/Psmc3ip^tm1Rdco	involves: 129S6/SvEvTac	MGI:3639079
cx2	Mnd1^{Gt(RRS590)Byg}/Mnd1^{Gt(RRS590)Byg} Psmc3ip^tm1Rdco/Psmc3ip^tm1Rdco	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	MGI:5577180
cx3	Psmc3ip^tm1Rdco/Psmc3ip^tm1Rdco Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc	involves: 129S6/SvEvTac * C57BL/6	MGI:5538720

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

absent gametes ( J:109004 )

azoospermia ( J:109004 )

abnormal meiosis ( J:109004 )

• homologous chromosomes are not assembled into the synaptonemal complex

abnormal male meiosis ( J:194067 , J:207221 )


	• male germ cells lack double strand breaks and are defective recombination and synapsis (J:194067) • however, preleptotene pairing is normal (J:194067)

arrest of male meiosis ( J:109004 )

• primary spermatocytes represent the most advanced spermatogenic cells

• arrest at the stage of pachytene-like chromosome condensation

absent ovarian follicles ( J:109004 )

abnormal ovary development ( J:109004 )

• show ovarian tubulostromal hyperplasia

testis hypoplasia ( J:109004 )

• with hyperplasia of interstitial cells

• approximately 30% of the size of the wild-type

infertility ( J:109004 )

• in both sexes

• do not show gross changes in any of the 32 somatic tissues examined

• homozygous mutants are born at normal Mendelian distribution

endocrine/exocrine glands

absent ovarian follicles ( J:109004 )

abnormal ovary development ( J:109004 )

• show ovarian tubulostromal hyperplasia

testis hypoplasia ( J:109004 )

• with hyperplasia of interstitial cells

• approximately 30% of the size of the wild-type

cellular

absent gametes ( J:109004 )

azoospermia ( J:109004 )

abnormal meiosis ( J:109004 )

• homologous chromosomes are not assembled into the synaptonemal complex

abnormal male meiosis ( J:194067 , J:207221 )


	• male germ cells lack double strand breaks and are defective recombination and synapsis (J:194067) • however, preleptotene pairing is normal (J:194067)

arrest of male meiosis ( J:109004 )

• primary spermatocytes represent the most advanced spermatogenic cells

• arrest at the stage of pachytene-like chromosome condensation

Allelic Composition	Mnd1^{Gt(RRS590)Byg}/Mnd1^{Gt(RRS590)Byg} Psmc3ip^tm1Rdco/Psmc3ip^tm1Rdco
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mnd1^{Gt(RRS590)Byg} mutation (0 available); any Mnd1 mutation (14 available)
Psmc3ip^tm1Rdco mutation (0 available); any Psmc3ip mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal male meiosis ( J:207221 )

• homologous chromosomes fails to synapse in some cases

cellular

abnormal male meiosis ( J:207221 )

• homologous chromosomes fails to synapse in some cases

abnormal double-strand DNA break repair ( J:207221 )

• defects in double-strand break repair

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:207221 )

• defects in double-strand break repair

Allelic Composition	Psmc3ip^tm1Rdco/Psmc3ip^tm1Rdco Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmc3ip^tm1Rdco mutation (0 available); any Psmc3ip mutation (7 available)
Spo11^tm1.1Gvpc mutation (0 available); any Spo11 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

The number of meiotic double stranded breaks is reduced in Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc and Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc Psmc3ip^tm1Rdco/Psmc3ip^tm1Rdco females

cellular

abnormal double-strand DNA break repair ( J:202231 )

• decreased number of meiotic double strand breaks in spermatocytes and oocytes; more so in oocytes than spermatocytes

• deficiency of double strand breaks at the chromosomal ends

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:202231 )

• decreased number of meiotic double strand breaks in spermatocytes and oocytes; more so in oocytes than spermatocytes

• deficiency of double strand breaks at the chromosomal ends

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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