Phenotypes associated with this allele

• Allele Symbol: Del(9Apoa1-Apoa4)1Hmez
• Allele Name: deletion, Chr 9, Hafid Mezdour 1
• Allele ID: MGI:3628802
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Del(9Apoa1-Apoa4)1Hmez/Del(9Apoa1-Apoa4)1Hmez	involves: 129P2/OlaHsd * C57BL/6	MGI:3629714

Genotype
MGI:3629714

hm1

• Allelic Composition: Del(9Apoa1-Apoa4)1Hmez/Del(9Apoa1-Apoa4)1Hmez
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating cholesterol level ( J:109005 )

• lower than those of wild-type control by 68%

decreased circulating HDL cholesterol level ( J:109005 )

• lower than those of wild-type control by 83%

• after feeding a high fat western diet for 16 weeks HDL was decreased further

decreased circulating triglyceride level ( J:109005 )

• lower than those of wild-type control by 29%

• decrease was significant only in females

cardiovascular system

increased susceptibility to atherosclerosis ( J:109005 )

• when fed high fat western diet for 16 weeks, small but detectable atherosclerotic lesions with fatty streaks with small populations of foam cells near the aortic valve attachment site were found in some animals

hematopoietic system

increased macrophage derived foam cell number ( J:109005 )

• small populations of foam cells were found near the aortic valve attachment site in some animals

immune system

increased macrophage derived foam cell number ( J:109005 )

• small populations of foam cells were found near the aortic valve attachment site in some animals

cellular

increased macrophage derived foam cell number ( J:109005 )

• small populations of foam cells were found near the aortic valve attachment site in some animals