Phenotypes associated with this allele

• Allele Symbol: Nme1^tm1Jyd
• Allele Name: targeted mutation 1, Jean-Yves Daniel
• Allele ID: MGI:3628812
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nme1^tm1Jyd/Nme1^tm1Jyd	129-Nme1^tm1Jyd	MGI:3629074
hm2	Nme1^tm1Jyd/Nme1^tm1Jyd	B6.129-Nme1^tm1Jyd	MGI:3629073
hm3	Nme1^tm1Jyd/Nme1^tm1Jyd	involves: 129/Sv * C57BL/6	MGI:3629072

Genotype
MGI:3629074

hm1

• Allelic Composition: Nme1^tm1Jyd/Nme1^tm1Jyd
• Genetic Background: 129-Nme1^tm1Jyd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:109190 )

• Background Sensitivity: at N10, mortality in litters from homozygous matings in the early postnatal period is 2.2-fold greater than that observed in the F2 mixed background homozygous matings

• Background Sensitivity: at N10, progeny survival is improved with the number of pregnancies the females had experienced, although survival never exceeds 50%

growth/size/body

decreased body weight ( J:109190 )

• homozygotes have a significantly lower (20-25%) body weight than controls

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:109190 )

♀ • in 15-week old virgin mice, ductal branching is poor and the fat pad is not completely filled

abnormal lactation ( J:109190 )

♀ • homozygous or heterozygous pups are not fed by Nme1-deficient females and usually die from dehydration; homozygous pups do have a normal suckling reflex

integument

abnormal branching of the mammary ductal tree ( J:109190 )

♀ • in 15-week old virgin mice, ductal branching is poor and the fat pad is not completely filled

abnormal lactation ( J:109190 )

♀ • homozygous or heterozygous pups are not fed by Nme1-deficient females and usually die from dehydration; homozygous pups do have a normal suckling reflex

Genotype
MGI:3629073

hm2

• Allelic Composition: Nme1^tm1Jyd/Nme1^tm1Jyd
• Genetic Background: B6.129-Nme1^tm1Jyd

mortality/aging

postnatal lethality, incomplete penetrance ( J:109190 )

• Background Sensitivity: at N10, mortality in litters from homozygous matings in the early postnatal period is 1.7-fold greater than that observed in litters from F2 generation homozygotes on the mixed background

• Background Sensitivity: progeny mortality is fixed around 90%

growth/size/body

decreased body weight ( J:109190 )

• homozygotes have a significantly lower (20-25%) body weight than controls

cellular

maternal effect ( J:109190 )

• when female nulls are bred to wild-type males, life expectancy of progeny is similar to that when both parents are homozygous for Nme1^tm1Jyd; survival of progeny is drastically reduced

Genotype
MGI:3629072

hm3

• Allelic Composition: Nme1^tm1Jyd/Nme1^tm1Jyd
• Genetic Background: involves: 129/Sv * C57BL/6

mortality/aging

postnatal lethality, incomplete penetrance ( J:109190 )

• F2 homozygotes show a 4-fold increase in mortality in the first 3 days after birth compared to wild-type controls

• Background Sensitivity: in the F6 generation, mortality is 4-fold lower than in the F2 generation; on congenic (N10) backgrounds, mortality is 2x greater than in the F2 mixed background

growth/size/body

decreased body weight ( J:109190 )

• F2 pups are significantly smaller (20-25%) than wild-type littermates at birth; this difference is maintained through weaning into adulthood

• Background Sensitivity: weight difference between homozygotes and wild-type disappears after the fourth generation of intercross

nervous system

abnormal innervation ( J:109190 )

• in an F6 mixed background, Nme1-deficiency appears to affect ex vivo neurofilament organization of peripheral nerve cells

liver/biliary system

impaired liver regeneration ( J:109190 )

• on this mixed background, liver regeneration in homozygotes is decreased by 75% in 48 hours in response to removal of the left lateral lobe

neoplasm

increased lymphoma incidence ( J:109190 )

• 8/10 F2 female mice maintained to 18 months of age developed highly metastatic spontaneous lymphomas compared to 2/7 wild-type controls

cellular

maternal effect ( J:109190 )

• on the F4 mixed background when the female parent is wild-type, life expectancy of heterozygous or wild-type progeny is comparable to that of offspring of wild-type matings; when female nulls are bred to wild-type males, life expectancy of progeny is similar to that when both parents are homozygous for Nme1^tm1Jyd