Phenotypes associated with this allele

• Allele Symbol: Flt3^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:3628823
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Flt3^m1Btlr/Flt3^m1Btlr	C57BL/6J-Flt3^m1Btlr	MGI:4459510

Genotype
MGI:4459510

hm1

• Allelic Composition: Flt3^m1Btlr/Flt3^m1Btlr
• Genetic Background: C57BL/6J-Flt3^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:159599 )

• 100% die due to mouse cytomegalovirus exposure

immune system

decreased dendritic cell number ( J:159599 )

• conventional DCs are reduced in bone marrow and spleen

decreased plasmacytoid dendritic cell number ( J:159599 )

• both the number and percentage of pDCs are reduced in bone marrow and spleen

decreased NK cell number ( J:159599 )

• splenic NK cells are reduced in percentage and number, bone marrow NK cells are only moderately reduced

decreased splenocyte number ( J:159599 )

• spleens and lymph nodes are consistently smaller and show reduced cellularity

abnormal NK cell physiology ( J:159599 )

• failure of CD69 upregulation 6 hours after mouse cytomegalovirus infection

abnormal macrophage physiology ( J:105543 )

• the susceptibility of activated mutant macrophages to ex vivo vesicular stomatitis virus (VSV) infection was reversed by the addition of type I interferon

decreased circulating interferon-alpha level ( J:159599 )

• is moderately not significantly reduced in the serum

decreased circulating interferon-gamma level ( J:159599 )

decreased circulating interleukin-12 level ( J:159599 )

• is moderately but not significantly reduced in the serum

increased circulating interleukin-6 level ( J:159599 )

• 36 hours after mouse cytomegalovirus infection

increased circulating tumor necrosis factor level ( J:159599 )

• 36 hours after mouse cytomegalovirus infection

small lymph nodes ( J:159599 )

abnormal dendritic cell physiology ( J:159599 )

• abnormal cytokine responses of splenic DC populations in response to MCMV infection or stimulation by TLR7 or TLR9 ligands

abnormal dendritic cell antigen presentation ( J:159599 )

• DCs show a moderate defect in an in vivo assay for T cell proliferation dependent on antigen cross presentation by DCs

decreased interferon-alpha secretion ( J:159599 )

• by splenic DC populations in response to MCMV infection or stimulation by TLR7 or TLR9 ligands

decreased interferon-gamma secretion ( J:159599 )

• a reduced percentage of NK cells produced IFN-gamma 24 hours after mouse cytomegalovirus infection

decreased interleukin-12 secretion ( J:159599 )

• by splenic DC populations in response to MCMV infection or stimulation by TLR7 or TLR9 ligands

increased susceptibility to Herpesvirales infection ( J:105543 )

• mice are susceptible to infection by mouse cytomegalovirus (MCMV)

• mice are severely ill and have high viral loads in the spleen five days following infection with MCMV

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:159599 )

• 100% die due to mouse cytomegalovirus exposure

increased susceptibility to Riboviria infection ( J:105543 )

• activated macrophages from these mice are susceptible to ex vivo VSV infection

hematopoietic system

decreased dendritic cell number ( J:159599 )

• conventional DCs are reduced in bone marrow and spleen

decreased plasmacytoid dendritic cell number ( J:159599 )

• both the number and percentage of pDCs are reduced in bone marrow and spleen

decreased NK cell number ( J:159599 )

• splenic NK cells are reduced in percentage and number, bone marrow NK cells are only moderately reduced

decreased splenocyte number ( J:159599 )

• spleens and lymph nodes are consistently smaller and show reduced cellularity

abnormal NK cell physiology ( J:159599 )

• failure of CD69 upregulation 6 hours after mouse cytomegalovirus infection

abnormal macrophage physiology ( J:105543 )

• the susceptibility of activated mutant macrophages to ex vivo vesicular stomatitis virus (VSV) infection was reversed by the addition of type I interferon

growth/size/body

decreased body weight ( J:159599 )

• slightly smaller than wild-type

homeostasis/metabolism

decreased circulating interferon-alpha level ( J:159599 )

• is moderately not significantly reduced in the serum

decreased circulating interferon-gamma level ( J:159599 )

decreased circulating interleukin-12 level ( J:159599 )

• is moderately but not significantly reduced in the serum

increased circulating interleukin-6 level ( J:159599 )

• 36 hours after mouse cytomegalovirus infection

increased circulating tumor necrosis factor level ( J:159599 )

• 36 hours after mouse cytomegalovirus infection