Phenotypes associated with this allele

• Allele Symbol: Kat6a^tm1Iki
• Allele Name: targeted mutation 1, Issay Kitabayashi
• Allele ID: MGI:3629032
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kat6a^tm1Iki/Kat6a^tm1Iki	Not Specified	MGI:3696775

Genotype
MGI:3696775

hm1

• Allelic Composition: Kat6a^tm1Iki/Kat6a^tm1Iki
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:108699 )

hematopoietic system

absent common myeloid progenitor cells ( J:108699 )

• total colony-forming cells (CFCs) is decreased 5-10 fold in fetal liver

abnormal erythropoiesis ( J:108699 )

• differentiated red cells are severely reduced, while late-stage erythroblasts are elevated in mutants

abnormal myelopoiesis ( J:108699 )

• granulocyte and monocyte cell populations are increased compared to controls

decreased B cell number ( J:108699 )

• CD19+ cells are reduced compared to controls

decreased hematopoietic stem cell number ( J:108699 )

• hematopoietic stem cells (HSCs) and lineage-committed progenitor cells is reduced

immune system

abnormal myelopoiesis ( J:108699 )

• granulocyte and monocyte cell populations are increased compared to controls

decreased B cell number ( J:108699 )

• CD19+ cells are reduced compared to controls

homeostasis/metabolism

skin edema ( J:108699 )

• some embryos display subcutaneous edema

liver/biliary system

small liver ( J:108699 )

• liver is smaller than wild-type at E14.5

liver hypoplasia ( J:108699 )

• at E14.5, total number of fetal liver cells is reduced 40%

cardiovascular system

hemorrhage ( J:108699 )

• some embryos exhibit hemorrhaging

limbs/digits/tail

abnormal tail morphology ( J:108699 )

• some embryos have bent tails

integument

skin edema ( J:108699 )

• some embryos display subcutaneous edema

pallor ( J:108699 )

• at E14.5, embryos are pale