Phenotypes associated with this allele

• Allele Symbol: Ppard^tm1Mtz
• Allele Name: targeted mutation 1, Daniel Metzger
• Allele ID: MGI:3629067
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ppard^tm1Mtz/Ppard^tm1Mtz Tg(KRT14-cre)1Ipc/0	involves: C57BL/6 * SJL	MGI:3629414

Genotype
MGI:3629414

cn1

• Allelic Composition: Ppard^tm1Mtz/Ppard^tm1Mtz; Tg(KRT14-cre)1Ipc/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased cholesterol level ( J:109090 )

• there is a marked decrease in cholesterol in newborns

integument

abnormal skin morphology ( J:109090 )

• phenotype of newborn mutant epidermis is identical to that observed in Rxr loss-of-function newborns

abnormal epidermal layer morphology ( J:109090 )

• sqaumes from newborn mice display a smooth surface with small or lacking corneodesmosomes (CDs), compared to wild-type which have numerous regularly spaced plaques corresponding to CDs

abnormal keratinocyte morphology ( J:109090 )

abnormal skin condition ( J:109090 )

• skin of newborns appears dull