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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cxcl1tm1Wabo
targeted mutation 1, William A Boisvert
MGI:3629087
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Cxcl1tm1Wabo/Cxcl1tm1Wabo
Ldlrtm1Her/Ldlrtm1Her 		involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 MGI:3629493


Genotype
MGI:3629493
cx1
Allelic
Composition		 Cxcl1tm1Wabo/Cxcl1tm1Wabo
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl1tm1Wabo mutation (0 available); any Cxcl1 mutation (12 available)
Ldlrtm1Her mutation (19 available); any Ldlr mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased susceptibility to atherosclerosis ( J:107325 )
• double knockouts are less susceptible than Ldlrtm1Her single knockouts
atherosclerotic lesions ( J:107325 )
• surface lesions in aortas are significantly smaller than those in Ldlrtm1Her homozygous, Cxcl wild-type littermates (14.2% vs 17.1%)
• lesion area in the aoritic valve is smaller than in littermates (186,423 micron2 vs 238636 micron2
• there is less macrophage accumualation in lesions of double knockouts than in control single mutants




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory