Phenotypes associated with this allele

• Allele Symbol: Ecel1^tm1Jroh
• Allele Name: targeted mutation 1, Jack Rohrer
• Allele ID: MGI:3629091
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ecel1^tm1Jroh/Ecel1^tm1Jroh	involves: 129P2/OlaHsd * C57BL/6	MGI:3687334

Genotype
MGI:3687334

hm1

• Allelic Composition: Ecel1^tm1Jroh/Ecel1^tm1Jroh
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Congenital atelectasis in Ecel1^tm1Jroh/Ecel1^tm1Jroh lungs

mortality/aging

neonatal lethality, complete penetrance ( J:56300 )

• 100% die of respiratory failure shortly (within 10-30 min) after birth

respiratory system

atelectasis ( J:56300 )

• lungs are never ventilated and remain atelectatic after birth

• 15 of 20 show congenital atelectasis

respiratory failure ( J:56300 )

• die of respiratory failure shortly after birth

homeostasis/metabolism

cyanosis ( J:56300 )

anoxia ( J:56300 )

• die of anoxia within 10-30 minutes after birth

cardiovascular system

cardiovascular system phenotype ( J:56300 )

N • heart beat is normal

nervous system

nervous system phenotype ( J:56300 )

N • medulla oblongata, the brain stem, spinal chord, and putamen are normal

skeleton

skeleton phenotype ( J:56300 )

N • do not exhibit any skeletal, craniofacial or cartilage defects