Phenotypes associated with this allele

• Allele Symbol: Tg(ITGAM-cre)2781Gkl
• Allele Name: transgene insertion 2781, George Kollias
• Allele ID: MGI:3629092
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Grn^tm1Far/Grn^tm1Far Tg(ITGAM-cre)2781Gkl/0	involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N	MGI:5444201
cn2	Tg(ITGAM-cre)2781Gkl/0 Tg(SOD1*G37R)1Dwc/0	involves: C57BL/6 * CBA	MGI:3629233
cn3	Ptger2^tm1.1Kand/Ptger2^tm1.1Kand Tg(ITGAM-cre)2781Gkl/0	involves: C57BL/6 * CBA	MGI:5559329

Genotype
MGI:5444201

cn1

• Allelic Composition: Grn^tm1Far/Grn^tm1Far; Tg(ITGAM-cre)2781Gkl/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased susceptibility to dopaminergic neuron neurotoxicity ( J:188324 )

• induced by MPTP

microgliosis ( J:188324 )

• in MPTP-treated mice

loss of dopaminergic neurons ( J:188324 )

• greater in mice treated with MPTP compared with control mice

homeostasis/metabolism

increased susceptibility to dopaminergic neuron neurotoxicity ( J:188324 )

• induced by MPTP

cellular

increased susceptibility to dopaminergic neuron neurotoxicity ( J:188324 )

• induced by MPTP

hematopoietic system

microgliosis ( J:188324 )

• in MPTP-treated mice

immune system

microgliosis ( J:188324 )

• in MPTP-treated mice

Genotype
MGI:3629233

cn2

• Allelic Composition: Tg(ITGAM-cre)2781Gkl/0; Tg(SOD1*G37R)1Dwc/0
• Genetic Background: involves: C57BL/6 * CBA

mortality/aging

premature death ( J:109131 )

• expression of Cre in microglia extends the lifespan of mutant SOD1-expressing mice by an average of 99 days compared to non-ITGAM-cre expressing mice

nervous system

axon degeneration ( J:109131 )

• progression of later stage disease is slowed by an average of 75 days in mice expressing both transgenes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
amyotrophic lateral sclerosis type 1		DOID:0060193	OMIM:105400	J:109131

Genotype
MGI:5559329

cn3

• Allelic Composition: Ptger2^tm1.1Kand/Ptger2^tm1.1Kand; Tg(ITGAM-cre)2781Gkl/0
• Genetic Background: involves: C57BL/6 * CBA

immune system

abnormal microglial cell physiology ( J:202677 )

• expression analysis suggests a decrease in the inflammatory and proliferative state of microglia

decreased susceptibility to endotoxin shock ( J:202677 )

• expression analysis indicates a blunted systemic and brain innate immune response to systemic LPS treatment

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:202677 )

• decrease in the inflammatory response and microglial and astrocyte activation after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in the substantia nigra pars compacta

• however, no rescue of the loss of TH+ neurons in MPTP treated mice is detected

increased physiological sensitivity to xenobiotic ( J:202677 )

• increase in dopamine turnover in MPTP treated mutants compared to similarly treated controls

nervous system

abnormal microglial cell physiology ( J:202677 )

• expression analysis suggests a decrease in the inflammatory and proliferative state of microglia

hematopoietic system

abnormal microglial cell physiology ( J:202677 )

• expression analysis suggests a decrease in the inflammatory and proliferative state of microglia