Phenotypes associated with this allele

• Allele Symbol: Polm^tm1Abnd
• Allele Name: targeted mutation 1, Antonio Bernad
• Allele ID: MGI:3629201
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Polm^tm1Abnd/Polm^tm1Abnd	involves: 129/Sv * BALB/c	MGI:3629496

Genotype
MGI:3629496

hm1

• Allelic Composition: Polm^tm1Abnd/Polm^tm1Abnd
• Genetic Background: involves: 129/Sv * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal B cell number ( J:97782 )

• when Polm-deficient mice are immunized with a chicken gammaglobulin conjugate, after 15 days spleens show a 2-2.3 fold increase centroblasts in terms of absolute numbers and as a percentage of total B cells compared to wild-type; as early as 5 days post-immunization, there is a 2-fold increase in centroblasts compared to wild-type

• in Polm-deficient mice, there is a reduced mumber of highly mutated clones (>10 mutations) in young (12%) and old (5%) compared to wild-type

immune system

abnormal B cell number ( J:97782 )

• when Polm-deficient mice are immunized with a chicken gammaglobulin conjugate, after 15 days spleens show a 2-2.3 fold increase centroblasts in terms of absolute numbers and as a percentage of total B cells compared to wild-type; as early as 5 days post-immunization, there is a 2-fold increase in centroblasts compared to wild-type

• in Polm-deficient mice, there is a reduced mumber of highly mutated clones (>10 mutations) in young (12%) and old (5%) compared to wild-type