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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sohlh1tm1Rajk
targeted mutation 1, Aleksandar Rajkovic
MGI:3629211
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sohlh1tm1Rajk/Sohlh1tm1Rajk involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6 MGI:5817765
hm2
 		Sohlh1tm1Rajk/Sohlh1tm1Rajk involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 MGI:3630148


Genotype
MGI:5817765
hm1
Allelic
Composition		 Sohlh1tm1Rajk/Sohlh1tm1Rajk
Genetic
Background		 involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sohlh1tm1Rajk mutation (1 available); any Sohlh1 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased oocyte number ( J:110210 )
• ovaries contain few germ cells by 3 weeks of age
• however, newborn ovaries show a normal number of oocytes within germ cell clusters and primordial follicles
absent oocytes ( J:110210 )
• ovaries beyond 7 weeks of age lack germ cells
absent primary ovarian follicles ( J:110210 )
• ovaries lack primary follicles at P3
absent ovarian follicles ( J:110210 )
• ovaries beyond 7 weeks of age lack follicular structures
impaired ovarian folliculogenesis ( J:110210 )
• ovarian follicle development appears to be impaired during the primordial-to-primary follicle transition
• fewer advanced follicle types and empty follicles are observed at P7 with no oocytes remaining by 3 weeks of age
ovary atrophy ( J:110210 )
• ovaries are significantly smaller at P7 and atrophic by 10 weeks of age
• adult ovaries occupy only ~1/10 of wild-type volume
• however, newborn ovaries show normal morphology and histology
female infertility ( J:110210 )
• all females are infertile

cellular
decreased oocyte number ( J:110210 )
• ovaries contain few germ cells by 3 weeks of age
• however, newborn ovaries show a normal number of oocytes within germ cell clusters and primordial follicles
absent oocytes ( J:110210 )
• ovaries beyond 7 weeks of age lack germ cells

endocrine/exocrine glands
absent primary ovarian follicles ( J:110210 )
• ovaries lack primary follicles at P3
absent ovarian follicles ( J:110210 )
• ovaries beyond 7 weeks of age lack follicular structures
impaired ovarian folliculogenesis ( J:110210 )
• ovarian follicle development appears to be impaired during the primordial-to-primary follicle transition
• fewer advanced follicle types and empty follicles are observed at P7 with no oocytes remaining by 3 weeks of age
ovary atrophy ( J:110210 )
• ovaries are significantly smaller at P7 and atrophic by 10 weeks of age
• adult ovaries occupy only ~1/10 of wild-type volume
• however, newborn ovaries show normal morphology and histology




Genotype
MGI:3630148
hm2
Allelic
Composition		 Sohlh1tm1Rajk/Sohlh1tm1Rajk
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sohlh1tm1Rajk mutation (1 available); any Sohlh1 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:109310 )
• at 7 weeks of age, seminiferous tubules are hypocellular with clumps of Sertoli cells in the lumen
decreased testis weight ( J:109310 )
• at 3 weeks of age testes from homozygotes weigh ~one half that of wild-type or heterozygous testes; in adults, testes weighed 3.5-fold less than wild-type

reproductive system
abnormal seminiferous tubule morphology ( J:109310 )
• at 7 weeks of age, seminiferous tubules are hypocellular with clumps of Sertoli cells in the lumen
decreased testis weight ( J:109310 )
• at 3 weeks of age testes from homozygotes weigh ~one half that of wild-type or heterozygous testes; in adults, testes weighed 3.5-fold less than wild-type
abnormal spermatogenesis ( J:109310 )
• at 10 days of age, 90% of testes tubules do not contain spermatocytes; at 2 weeks, 65% of tubules do not contain spermatocytes and at 7 weeks tubules are devoid of spermatocytes
• in 8 month old males spermatogonia stem cells continue to proliferate but cannot differentiate into mature spermatocytes
male infertility ( J:109310 )
• males are infertile due to defective spermatogonial differentiation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/19/2024
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