All Phenotypes Xiap<tm1Vdr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Xiap^tm1Vdr
targeted mutation 1, J E Visvader
MGI:3629213

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Xiap^tm1Vdr/Xiap^tm1Vdr	B6.129S1-Xiap^tm1Vdr	MGI:3629920
hm2	Xiap^tm1Vdr/Xiap^tm1Vdr	involves: 129S1/Sv	MGI:5319376
cx3	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Ripk1^tm1Led/Ripk1^tm1Led Xiap^tm1Vdr/Xiap^tm1Vdr	involves: 129S1/Sv * 129S6/SvEvTac * BALB/cJ * C57BL/6	MGI:5319382
cx4	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Ripk1^tm1Led/Ripk1⁺ Xiap^tm1Vdr/Xiap^tm1Vdr	involves: 129S1/Sv * 129S6/SvEvTac * BALB/cJ * C57BL/6	MGI:5319383
cx5	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Xiap^tm1Vdr/Xiap^tm1Vdr	involves: 129S1/Sv * BALB/cJ * C57BL/6	MGI:5319375
cx6	Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Xiap^tm1Vdr/Xiap^tm1Vdr	involves: 129S1/Sv * C57BL/6 * SJL	MGI:5319377

Allelic Composition	Xiap^tm1Vdr/Xiap^tm1Vdr
Genetic Background	B6.129S1-Xiap^tm1Vdr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xiap^tm1Vdr mutation (0 available); any Xiap mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland development ( J:109330 )

• at days 16, 17 and 18 of pregnancy, there is reduced lobulo-alveolar development compared to wild-type controls; it is also apparent at day 0.5 of lactation but is not observed at day 7 of lactation

abnormal milk composition ( J:109330 )

• decreased production of alpha and beta casein and whey acidic protein is evident in mutants at days 16 and 18 of pregnancy, but is neglible at day 1.5 of lactation

hypolactation ( J:109330 )

• milk production is decreased at days 16 and 18 of pregnancy

integument

abnormal mammary gland development ( J:109330 )

abnormal milk composition ( J:109330 )

• decreased production of alpha and beta casein and whey acidic protein is evident in mutants at days 16 and 18 of pregnancy, but is neglible at day 1.5 of lactation

hypolactation ( J:109330 )

• milk production is decreased at days 16 and 18 of pregnancy

Allelic Composition	Xiap^tm1Vdr/Xiap^tm1Vdr
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xiap^tm1Vdr mutation (0 available); any Xiap mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:182515 )

• around E10.5

cardiovascular system

abnormal heart atrium morphology ( J:182515 )

• sporadic discontinuities associated with pyknotic nuclei suggestive of apoptosis, usually in the atrial chamber

enlarged pericardium ( J:182515 )

• between E10.5 and E11.5, many mice exhibit swollen pericardial cavities filled with blood unlike in wild-type mice

hemorrhage ( J:182515 )

hemopericardium ( J:182515 )

• between E10.5 and E11.5

decreased cardiac muscle contractility ( J:182515 )

• between E10.5 and E11.5, mice exhibit minimal or no contractile activity unlike in wild-type mice

congestive heart failure ( J:182515 )

homeostasis/metabolism

hemopericardium ( J:182515 )

• between E10.5 and E11.5

muscle

decreased cardiac muscle contractility ( J:182515 )

• between E10.5 and E11.5, mice exhibit minimal or no contractile activity unlike in wild-type mice

Allelic Composition	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Ripk1^tm1Led/Ripk1^tm1Led Xiap^tm1Vdr/Xiap^tm1Vdr
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2^tm1.1Rbr mutation (0 available); any Birc2 mutation (33 available)
Ripk1^tm1Led mutation (0 available); any Ripk1 mutation (33 available)
Xiap^tm1Vdr mutation (0 available); any Xiap mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:182515 )

• mice die by E15.5

Allelic Composition	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Ripk1^tm1Led/Ripk1⁺ Xiap^tm1Vdr/Xiap^tm1Vdr
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * BALB/cJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:182515 )

• most mice die within 10 weeks of birth

• however, two mice survive for 6 weeks

growth/size/body

decreased body size ( J:182515 )

• two surviving mice

Allelic Composition	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Xiap^tm1Vdr/Xiap^tm1Vdr
Genetic Background	involves: 129S1/Sv * BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2^tm1.1Rbr mutation (0 available); any Birc2 mutation (33 available)
Xiap^tm1Vdr mutation (0 available); any Xiap mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:182515 )

• around E10.5

cardiovascular system

abnormal heart atrium morphology ( J:182515 )

• sporadic discontinuities associated with pyknotic nuclei suggestive of apoptosis, usually in the atrial chamber

enlarged pericardium ( J:182515 )

• between E10.5 and E11.5, many mice exhibit swollen pericardial cavities filled with blood unlike in wild-type mice

hemorrhage ( J:182515 )

hemopericardium ( J:182515 )

• between E10.5 and E11.5

decreased cardiac muscle contractility ( J:182515 )

• between E10.5 and E11.5, mice exhibit minimal or no contractile activity unlike in wild-type mice

congestive heart failure ( J:182515 )

homeostasis/metabolism

hemopericardium ( J:182515 )

• between E10.5 and E11.5

muscle

decreased cardiac muscle contractility ( J:182515 )

• between E10.5 and E11.5, mice exhibit minimal or no contractile activity unlike in wild-type mice

Allelic Composition	Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Xiap^tm1Vdr/Xiap^tm1Vdr
Genetic Background	involves: 129S1/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc3^tm1.1Rbr mutation (0 available); any Birc3 mutation (32 available)
Xiap^tm1Vdr mutation (0 available); any Xiap mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:182515 )

• mice are viable and fertile and have a normal phenotype

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