All Phenotypes Trp53<tm2Xu> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^tm2Xu/Trp53^tm2Xu	involves: 129S6/SvEvTac	MGI:3630330
cx2	Trp53^tm2Xu/Trp53^tm2Xu Xrcc4^tm1Fwa/Xrcc4^tm1Fwa	involves: 129P2/OlaHsd * 129S6/SvEvTac	MGI:3630332

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:109354 )

• mice develop leukemias, fibrosarcomas, granuloma and adenomas; these are rarely seen in Trp53^tm1Tyj homozygous mice

increased tumor latency ( J:109354 )

• mice are cancer prone but develop tumors in a wide spectrum of tissues, with a delayed onset compared with Trp53-null mice which develop thymic lymphomas primarily within 6 months of age

hematopoietic system

decreased T cell apoptosis ( J:109354 )

• thymocytes are essentially resistant to Trp53-mediated apoptosis

decreased T cell proliferation ( J:109354 )

• proliferation of thymocytes after stimulation with PMA or Ionomycin is slower than Trp53^tm1Tyj cells at the later time point, but similar to wild-type at the earlier time point

immune system

decreased T cell apoptosis ( J:109354 )

• thymocytes are essentially resistant to Trp53-mediated apoptosis

decreased T cell proliferation ( J:109354 )

• proliferation of thymocytes after stimulation with PMA or Ionomycin is slower than Trp53^tm1Tyj cells at the later time point, but similar to wild-type at the earlier time point

cellular

decreased T cell apoptosis ( J:109354 )

• thymocytes are essentially resistant to Trp53-mediated apoptosis

decreased T cell proliferation ( J:109354 )

• proliferation of thymocytes after stimulation with PMA or Ionomycin is slower than Trp53^tm1Tyj cells at the later time point, but similar to wild-type at the earlier time point

Allelic Composition	Trp53^tm2Xu/Trp53^tm2Xu Xrcc4^tm1Fwa/Xrcc4^tm1Fwa
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm2Xu mutation (2 available); any Trp53 mutation (240 available)
Xrcc4^tm1Fwa mutation (0 available); any Xrcc4 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:109354 )

N	• embryonic lethality seen in Xrcc4^tm1Fwa homozygotes is rescued when crossed to a Trp53^tm2Xu mouse

growth/size/body

decreased body size ( J:109354 )

• mice are runted

reproductive system

testicular atrophy ( J:109354 )

• atrophy is detected with age

skeleton

kyphoscoliosis ( J:109354 )

• mice develop acute curvature of the spine as they age

neoplasm

abnormal tumor incidence ( J:109354 )

• double knockouts rarely develop tumors (only 2/34 develop thymic tumors at 93 and 128 days of age) compared with Trp53^tm2Xu homozygotes

integument

thin skin ( J:109354 )

• skin thickness is reduced with age

endocrine/exocrine glands

testicular atrophy ( J:109354 )

• atrophy is detected with age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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