Phenotypes associated with this allele

• Allele Symbol: Fgf10^{Tg(Myl3-lacZ)24Buck}
• Allele Name: transgene insertion 24, Margaret E Buckingham
• Allele ID: MGI:3629660
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Fgf10^tm1Ska/Fgf10^Tg(Myl3-lacZ)24Buck	involves: C57BL/6 * CBA	MGI:3629789

Genotype
MGI:3629789

ht1

• Allelic Composition: Fgf10^tm1Ska/Fgf10^{Tg(Myl3-lacZ)24Buck}
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:115048 )

• colon displays defined but shortened crypt

abnormal mammary placode morphology ( J:109476 )

♀ • placode 3 is not detected at E11.5 and E12.5

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:98521 )

• in mutants gelatinase activity in the lung mesenchyme is decreased

respiratory system

impaired branching involved in bronchus morphogenesis ( J:98521 )

• at E12.5, embryos have lungs with decreased branching

small lung ( J:98521 )

• at E12.5 mice have slightly smaller lungs than wild-type

abnormal pulmonary elastic fiber morphology ( J:98521 )

• at birth, elastin deposition around the bronchi is reduced compared to wild-type

digestive/alimentary system

abnormal intestinal epithelium morphology ( J:115048 )

• mice exhibit epithelial hypocellularity along the proximal-distal axis of the colon

abnormal large intestine crypts of Lieberkuhn morphology ( J:115048 )

• colon displays defined but shortened crypt

abnormal colon morphology ( J:115048 )

• at E18.5, the colon is 56% of wild-type length

• mid region exhibits enlarged lumen with rudimentary crypts and meconium accumulation in lumen

embryo

abnormal embryonic tissue morphology ( J:109476 )

• mutants fail to generate a stratum intermedium at E11.5

• cells of the stratum germinativum are still cuboidal at E11, not cylindrical

integument

abnormal mammary placode morphology ( J:109476 )

♀ • placode 3 is not detected at E11.5 and E12.5