All Phenotypes Tg(NPHS2-rtTA2*M2)1Jbk MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(NPHS2-rtTA2*M2)1Jbk
transgene insertion 1, Jeffrey B Kopp
MGI:3629962

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^tm1Sor Tg(NPHS2-rtTA2M2)1Jbk/Tg(NPHS2-rtTA2M2)1Jbk Tg(tetO-cre)LC1Bjd/Tg(tetO-cre)LC1Bjd	involves: 129S4/SvJaeSor * BALB/c * C57BL/6 * FVB/N	MGI:6402037
cn2	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^tm1Sor Tg(NPHS2-rtTA2M2)1Jbk/Tg(NPHS2-rtTA2M2)1Jbk Tg(tetO-cre)LC1Bjd/0	involves: 129S4/SvJaeSor * BALB/c * C57BL/6 * FVB/N	MGI:6402038
cn3	Wt1^tm1.1Ceng/Wt1^tm1.1Ceng Tg(tetO-cre)LC1Bjd/0 Tg(NPHS2-rtTA2*M2)1Jbk/0	involves: BALB/c * C57BL/6 * FVB/N	MGI:5512664
cx4	Lama5^tm3Jhm/Lama5^tm3Jhm Tg(NPHS2-rtTA2*M2)1Jbk/0 Tg(tetO-LAMA5)1Jhm/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB/N	MGI:5432562
cx5	Hprt1^{tm1(tetO-EGFP/Rac1)Shaw}/Y Tg(NPHS2-rtTA2M2)1Jbk/0	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:5559183
cx6	Tg(NPHS2-rtTA2*M2)1Jbk/0 Tg(tetO-RNAi:Vegfa)#Atuf/0	involves: FVB	MGI:5446897

Allelic Composition	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^tm1Sor Tg(NPHS2-rtTA2M2)1Jbk/Tg(NPHS2-rtTA2M2)1Jbk Tg(tetO-cre)LC1Bjd/Tg(tetO-cre)LC1Bjd
Genetic Background	involves: 129S4/SvJaeSor * BALB/c * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(NPHS2-rtTA2*M2)1Jbk mutation (1 available)
Tg(tetO-cre)LC1Bjd mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

aneuploidy ( J:285673 )

• in primary podocyte cell cultures from doxycycline-treated mice

homeostasis/metabolism

increased urine protein level ( J:285673 )

• in doxycycline-treated mice

increased susceptibility to xenobiotic induced morbidity/mortality ( J:285673 )

• within the first 3 weeks following treatment with a high dose (50 ug/g) of doxycycline

• however, a lower doxycycline dose (15 ug/g) that produces FSGS does not affect lethality

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:285673 )

• within the first 3 weeks following treatment with a high dose (50 ug/g) of doxycycline

• however, a lower doxycycline dose (15 ug/g) that produces FSGS does not affect lethality

renal/urinary system

increased urine protein level ( J:285673 )

• in doxycycline-treated mice

podocyte foot process effacement ( J:285673 )

• with vacuolization after 10 days in mice treated with doxycycline

decreased podocyte number ( J:285673 )

• reduced density in mice treated with doxycycline

glomerulosclerosis ( J:285673 )

• from 3 weeks of age, doxycycline-treated mice exhibit focal segmental glomerulosclerosis (FSGS) with adhesions, segmental accumulation of matrix, capillary hyalinosis, loss of capillaries, and declining glomerular numbers through 13 weeks unlike control mice

• however, mice do not develop FSGS when doxycycline is administered antenatally or at 10 and 11 days after birth or when mice are treated with a low dose of doxycycline (1.5 ug/g)

decreased renal glomerulus number ( J:285673 )

• in doxycycline-treated mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
focal segmental glomerulosclerosis		DOID:1312	OMIM:PS603278	J:285673

Allelic Composition	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^tm1Sor Tg(NPHS2-rtTA2M2)1Jbk/Tg(NPHS2-rtTA2M2)1Jbk Tg(tetO-cre)LC1Bjd/0
Genetic Background	involves: 129S4/SvJaeSor * BALB/c * C57BL/6 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:285673 )

N	• doxycycline-treated mice do not exhibit focal segmental glomerulosclerosis

Allelic Composition	Wt1^tm1.1Ceng/Wt1^tm1.1Ceng Tg(tetO-cre)LC1Bjd/0 Tg(NPHS2-rtTA2*M2)1Jbk/0
Genetic Background	involves: BALB/c * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(NPHS2-rtTA2*M2)1Jbk mutation (1 available)
Tg(tetO-cre)LC1Bjd mutation (2 available)
Wt1^tm1.1Ceng mutation (0 available); any Wt1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

albuminuria ( J:197989 )

• progressive in doxycycline-treated mice

glomerulosclerosis ( J:197989 )

• focal segmental glomerulosclerosis in doxycycline-treated mice

homeostasis/metabolism

albuminuria ( J:197989 )

• progressive in doxycycline-treated mice

Allelic Composition	Lama5^tm3Jhm/Lama5^tm3Jhm Tg(NPHS2-rtTA2*M2)1Jbk/0 Tg(tetO-LAMA5)1Jhm/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lama5^tm3Jhm mutation (0 available); any Lama5 mutation (153 available)
Tg(NPHS2-rtTA2*M2)1Jbk mutation (1 available)
Tg(tetO-LAMA5)1Jhm mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:185850 )

N	• when doxycycline is administered from E12 to E15 to pregnant animals, offspring do not develop proteinuria or hematuria, with no kidney disease at least to 6 months of age

Allelic Composition	Hprt1^{tm1(tetO-EGFP/Rac1)Shaw}/Y Tg(NPHS2-rtTA2M2)1Jbk/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^{tm1(tetO-EGFP/Rac1*)Shaw} mutation (0 available); any Hprt1 mutation (1279 available)
Tg(NPHS2-rtTA2*M2)1Jbk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

increased urine protein level ( J:206088 )

• after 2 days of doxycycline treatment

• however, proteinuria abates 1 week post-induction

podocyte foot process effacement ( J:206088 )

• segmental in doxycycline-treated mice

homeostasis/metabolism

increased urine protein level ( J:206088 )

• after 2 days of doxycycline treatment

• however, proteinuria abates 1 week post-induction

Allelic Composition	Tg(NPHS2-rtTA2*M2)1Jbk/0 Tg(tetO-RNAi:Vegfa)#Atuf/0
Genetic Background	involves: FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(NPHS2-rtTA2*M2)1Jbk mutation (1 available)
Tg(tetO-RNAi:Vegfa)#Atuf mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

decreased urine creatinine level ( J:189626 )

• in tamoxifen-treated mice

increased urine protein level ( J:189626 )

• in tamoxifen-treated mice

podocyte foot process effacement ( J:189626 )

• in tamoxifen-treated mice

abnormal renal glomerulus basement membrane morphology ( J:189626 )

• delamination in tamoxifen-treated mice

abnormal renal glomerulus morphology ( J:189626 )

• tamoxifen-treated mice exhibit decreased glomerular volume, mesangiolysis and glomerular microaneurisms compared with wild-type mice

abnormal glomerular filtration barrier morphology ( J:189626 )

• tamoxifen-treated mice exhibit damaged glomerular filtration barrier with swelling, vacuolization and decreased fenestration of endothelial cells; glomerular basement membrane lamination, expansion of the lamina densa, irregular thickening and interdigitations of the endothelium surface; and podocyte foot process effacement compared with wild-type mice

mesangiolysis ( J:189626 )

• in tamoxifen-treated mice

kidney failure ( J:189626 )

• in tamoxifen-treated mice

homeostasis/metabolism

increased circulating creatinine level ( J:189626 )

• in tamoxifen-treated mice

decreased urine creatinine level ( J:189626 )

• in tamoxifen-treated mice

increased urine protein level ( J:189626 )

• in tamoxifen-treated mice

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