Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Myh6-IGF1R)7Jmcm transgene insertion 7, Julie R McMullen MGI:3630255 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the heart weight/body weight ratio is significantly lower than in single Tg(Myh6-IGF1R)7Siz mice and not different from single Tg(Myh6-Pik3ca)1Siz mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• exhibit a significant increase in heart size, with an increase in the heart weight/body weight ratio
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• exhibit a significant increase in heart size, with an increase in the heart weight/body weight ratio
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the short axis and cell area of myocytes are significantly greater and the cell volume is about 46% greater than in wild-type
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• increase in heart size due to an increase in myocyte size, without any evidence of necrosis, fibrosis or myocyte disarray
• the heart weight/body weight and heart weight/tibial length ratios at 3 months of age are increased by about 38 and 34%, respectively
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• exhibit a greater augmentation of the hypertrophic response to a physiological stimulus (chronic swimming) than to a pathological stimulus (aortic banding)
• hearts of aortic banded mutants have significantly less interstitial fibrosis that aortic banded controls
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• fractional shortening is significantly greater (16%) and is maintained at 12-16 months of age
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• left ventricular systolic function, as assessed by fractional shortening, is 16% greater, indicating enhanced systolic function
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• the short axis and cell area of myocytes are significantly greater and the cell volume is about 46% greater than in wild-type
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• fractional shortening is significantly greater (16%) and is maintained at 12-16 months of age
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• increase in heart size due to an increase in myocyte size, without any evidence of necrosis, fibrosis or myocyte disarray
• the heart weight/body weight and heart weight/tibial length ratios at 3 months of age are increased by about 38 and 34%, respectively
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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