Analysis Tools|
Allele Symbol Allele Name Allele ID |
Msntm1Sts targeted mutation 1, Shoichiro Tsukita MGI:3630284 |
| Summary |
2 genotypes |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice develop normally and are fertile
• no obvious histological abnormalities are seen
• function of platelets, fibroblasts and mast cells appears similar to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• T cell egress from the thymus and immature B cell egress from the BM is impaired
• T and B cells showed delayed egress from lymphoid organs
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• T cell egress from the thymus and immature B cell egress from the BM is impaired
• T and B cells showed delayed egress from lymphoid organs
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• reduction in the total leukocyte count, to 43% of the level in littermate controls
• number of cells was decreased in all leukocyte subsets examined, except for the Gr-1+ monocyte subset
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• in lymph nodes but not in spleen
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• weight loss and increased mortality of male mutant mice is seen upon treatment with bleomycin
• severe lung injury upon bleomycin treatment is seen in male mutant mice compared with controls
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• T cell egress from the thymus and immature B cell egress from the BM is impaired
• T and B cells showed delayed egress from lymphoid organs
|
|
• reduction in the total leukocyte count, to 43% of the level in littermate controls
• number of cells was decreased in all leukocyte subsets examined, except for the Gr-1+ monocyte subset
|
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• in lymph nodes but not in spleen
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• a significant increase in the size of the distal alveoli is seen in male mutant mice compared with controls
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• the air spaces of untreated adult male mutant mice are markedly enlarged, without signs of inflammation or alveolar destruction
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• mice develop normally and are fertile
• no obvious histological abnormalities are seen
• function of platelets, fibroblasts and mast cells appears similar to controls
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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