Phenotypes associated with this allele

• Allele Symbol: Tg(ACTA1-IGF1)1Rjs
• Allele Name: transgene insertion 1, Robert J Schwartz
• Allele ID: MGI:3630335
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(ACTA1-IGF1)1Rjs/0	involves: FVB	MGI:3630336

Genotype
MGI:3630336

tg1

• Allelic Composition: Tg(ACTA1-IGF1)1Rjs/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal myocardial fiber morphology ( J:58354 )

• myofiber hypertrophy and disorganization in 52-week old mutants

abnormal cardiac muscle contractility ( J:58354 )

• peak aortic velocity, a measure of systolic performance, is greater at 10 weeks of age but is not maintained and is no different at 20 or 32 weeks of age and is reduced by 52 weeks of age, indicating an initial benefit to systolic function early in life but compromised performance in aged mice

• early/atrial peak filling velocity ratios are consistently lower in mutants

increased skeletal muscle fiber size ( J:25522 )

• exhibit an increase in the cross-sectional area of myofibers and a shift toward more oxidative fiber types (likely types 2A and 2X)

cardiovascular system

abnormal myocardial fiber morphology ( J:58354 )

• myofiber hypertrophy and disorganization in 52-week old mutants

cardiac hypertrophy ( J:58354 )

• cardiac mass and cardiac mass/tibial length ratio are significantly greater by 10 weeks of age and increase until 20 weeks of age

• 52-week old mutants show myofiber hypertrophy

cardiac interstitial fibrosis ( J:58354 )

• seen in older mutants (72 weeks of age)

abnormal cardiac muscle contractility ( J:58354 )

• peak aortic velocity, a measure of systolic performance, is greater at 10 weeks of age but is not maintained and is no different at 20 or 32 weeks of age and is reduced by 52 weeks of age, indicating an initial benefit to systolic function early in life but compromised performance in aged mice

• early/atrial peak filling velocity ratios are consistently lower in mutants

growth/size/body

growth/size/body region phenotype ( J:25522 )

N • exhibit normal body weight most likely due to normal (not elevated) IGF1 concentrations in the serum

cardiac hypertrophy ( J:58354 )

• cardiac mass and cardiac mass/tibial length ratio are significantly greater by 10 weeks of age and increase until 20 weeks of age

• 52-week old mutants show myofiber hypertrophy

cellular

cardiac interstitial fibrosis ( J:58354 )

• seen in older mutants (72 weeks of age)