Analysis Tools
growth/size/body
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• cardiomegaly due to increased number of cells of in the heart
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• heart weight is normal up to 45 days of age but is increased 42%, 45%, 62%, and 51% at 75, 135, 210, and 300 days, respectively
• the heart weight/body weight ratio is increased 32%, 35%, 40%, and 35% at 75, 135, 210, and 300 days of age, respectively
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• progressive increase in the number of cells in the heart; 21%, 31%, and 55% increase in myocyte numbers at 45, 75, and 210 days of age
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• body weight is normal up to 135 days of age, however at 210 and 300 days, mutants weigh 15% and 12% more than controls
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• kidney weight is increased at 135 and 300 days of age but not earlier
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• liver weight is increased 11% at 45 days and 35% at 300 days of age
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• spleen weight is increased at 135 and 300 days of age but not earlier
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cardiovascular system
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• cardiomegaly due to increased number of cells of in the heart
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• heart weight is normal up to 45 days of age but is increased 42%, 45%, 62%, and 51% at 75, 135, 210, and 300 days, respectively
• the heart weight/body weight ratio is increased 32%, 35%, 40%, and 35% at 75, 135, 210, and 300 days of age, respectively
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• progressive increase in the number of cells in the heart; 21%, 31%, and 55% increase in myocyte numbers at 45, 75, and 210 days of age
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liver/biliary system
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• liver weight is increased 11% at 45 days and 35% at 300 days of age
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nervous system
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• brain weight is increased 7% at 45 days of age but not at 30 days
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renal/urinary system
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• kidney weight is increased at 135 and 300 days of age but not earlier
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hematopoietic system
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• spleen weight is increased at 135 and 300 days of age but not earlier
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immune system
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• spleen weight is increased at 135 and 300 days of age but not earlier
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