Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Myh6-Akt1*T308D*S473D)1Siz transgene insertion 1, Seigo Izumo MGI:3639116 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the heart weight/body weight ratio is similar to that of single Tg(Myh6-Akt1*T308D*S473D)1Siz mice
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• the heart weight/body weight ratio is similar to that of single Tg(Myh6-Akt1*T308D*S473D)1Siz mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• survive to a mean age of 15 weeks; most die after showing signs of heart failure
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• myocyte hypertrophy; the long axis is increased 1.3-fold, the short axis is increased 1.2-fold, the cell area is increased 1.5-fold, and the cell volume is increased 1.9-fold
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• the heart weight/body weight ratio is increased 2.2-fold at 2 and 14 weeks of age
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• significant increase in wall thickness of both the anterior and posterior left ventricular walls at 2 and 14 weeks of age
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• at 14 weeks of age, but not at 2 weeks, the left ventricular (LV) systolic diameter is increased, the LV diastolic diameter is minimally increased, and fractional shortening is decreased to 37%
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• myocyte hypertrophy; the long axis is increased 1.3-fold, the short axis is increased 1.2-fold, the cell area is increased 1.5-fold, and the cell volume is increased 1.9-fold
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• at 14 weeks of age, but not at 2 weeks, the left ventricular (LV) systolic diameter is increased, the LV diastolic diameter is minimally increased, and fractional shortening is decreased to 37%
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• the heart weight/body weight ratio is increased 2.2-fold at 2 and 14 weeks of age
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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