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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Myh6-Akt1*T308D*S473D)1Siz
transgene insertion 1, Seigo Izumo
MGI:3639116
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(Myh6-Akt1*T308D*S473D)1Siz/0
Tg(Myh6-Pik3ca)1Siz/0
involves: FVB/N MGI:3639125
tg2
Tg(Myh6-Akt1*T308D*S473D)1Siz/0 Not Specified MGI:3639117


Genotype
MGI:3639125
cx1
Allelic
Composition
Tg(Myh6-Akt1*T308D*S473D)1Siz/0
Tg(Myh6-Pik3ca)1Siz/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• the heart weight/body weight ratio is similar to that of single Tg(Myh6-Akt1*T308D*S473D)1Siz mice

growth/size/body
• the heart weight/body weight ratio is similar to that of single Tg(Myh6-Akt1*T308D*S473D)1Siz mice




Genotype
MGI:3639117
tg2
Allelic
Composition
Tg(Myh6-Akt1*T308D*S473D)1Siz/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• survive to a mean age of 15 weeks; most die after showing signs of heart failure

cardiovascular system
• myocyte hypertrophy; the long axis is increased 1.3-fold, the short axis is increased 1.2-fold, the cell area is increased 1.5-fold, and the cell volume is increased 1.9-fold
• the heart weight/body weight ratio is increased 2.2-fold at 2 and 14 weeks of age
• significant increase in wall thickness of both the anterior and posterior left ventricular walls at 2 and 14 weeks of age
• at 14 weeks of age, but not at 2 weeks, the left ventricular (LV) systolic diameter is increased, the LV diastolic diameter is minimally increased, and fractional shortening is decreased to 37%

muscle
• myocyte hypertrophy; the long axis is increased 1.3-fold, the short axis is increased 1.2-fold, the cell area is increased 1.5-fold, and the cell volume is increased 1.9-fold
• at 14 weeks of age, but not at 2 weeks, the left ventricular (LV) systolic diameter is increased, the LV diastolic diameter is minimally increased, and fractional shortening is decreased to 37%

growth/size/body
• the heart weight/body weight ratio is increased 2.2-fold at 2 and 14 weeks of age

cellular





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory