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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Myh6-Akt1)20Anr
transgene insertion 20, Anthony Rosenzweig
MGI:3639137
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
tg1
 		Tg(Myh6-Akt1)20Anr/Y involves: C57BL/6 MGI:3639142
tg2
 		Tg(Myh6-Akt1)20Anr/0 involves: C57BL/6 MGI:3653727


Genotype
MGI:3639142
tg1
Allelic
Composition		 Tg(Myh6-Akt1)20Anr/Y
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiac hypertrophy ( J:77257 )
• the heart weight/body weight ratio is 1.7-fold greater than in wild-type male littermates
heart left ventricle hypertrophy ( J:77257 )
• exhibit left ventricle hypertrophy that is slightly more marked in males than females, however systolic ventricular function is normal
thick ventricular wall ( J:77257 )
• increase in left ventricular wall thickness
decreased myocardial infarct size ( J:77257 )
• infarct size after coronary ligation is reduced by about 50% compared with controls

homeostasis/metabolism
decreased myocardial infarct size ( J:77257 )
• infarct size after coronary ligation is reduced by about 50% compared with controls

growth/size/body
cardiac hypertrophy ( J:77257 )
• the heart weight/body weight ratio is 1.7-fold greater than in wild-type male littermates
heart left ventricle hypertrophy ( J:77257 )
• exhibit left ventricle hypertrophy that is slightly more marked in males than females, however systolic ventricular function is normal

muscle
heart left ventricle hypertrophy ( J:77257 )
• exhibit left ventricle hypertrophy that is slightly more marked in males than females, however systolic ventricular function is normal




Genotype
MGI:3653727
tg2
Allelic
Composition		 Tg(Myh6-Akt1)20Anr/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal myocardial fiber morphology ( J:77257 )
• myocytes show significant heterogeneity in size
cardiac hypertrophy ( J:77257 )
• the heart weight/body weight ratio is 1.6-fold greater than in wild-type female littermates
heart left ventricle hypertrophy ( J:77257 )
• exhibit left ventricle hypertrophy that is slightly less marked in females than males, however systolic ventricular function is normal
decreased myocardial infarct size ( J:77257 )
• infarct size after coronary ligation is reduced by about 50% compared with controls

muscle
abnormal myocardial fiber morphology ( J:77257 )
• myocytes show significant heterogeneity in size
heart left ventricle hypertrophy ( J:77257 )
• exhibit left ventricle hypertrophy that is slightly less marked in females than males, however systolic ventricular function is normal

homeostasis/metabolism
decreased myocardial infarct size ( J:77257 )
• infarct size after coronary ligation is reduced by about 50% compared with controls

growth/size/body
cardiac hypertrophy ( J:77257 )
• the heart weight/body weight ratio is 1.6-fold greater than in wild-type female littermates
heart left ventricle hypertrophy ( J:77257 )
• exhibit left ventricle hypertrophy that is slightly less marked in females than males, however systolic ventricular function is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory