Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-Prkaa2*D157A)1Rti
• Allele Name: transgene insertion 1, Rong Tian
• Allele ID: MGI:3639282
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Myh6-Prkaa2*D157A)1Rti/0 Tg(Myh6-PRKAG2*T400N)1Feah/0	involves: FVB	MGI:4818887
tg2	Tg(Myh6-Prkaa2*D157A)1Rti/0	involves: FVB	MGI:3639283

Genotype
MGI:4818887

cx1

• Allelic Composition: Tg(Myh6-Prkaa2*D157A)1Rti/0; Tg(Myh6-PRKAG2*T400N)1Feah/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased cardiac muscle glycogen level ( J:123005 )

• myocytes exhibit increased glycogen content compared with wild-type cells that is not as severe as in myocytes from Tg(Myh6-PRKAG2*T400N)1Feah mice

increased heart weight ( J:123005 )

• mice exhibit increased heart weight compared with wild-type mice that is not as severe as in Tg(Myh6-PRKAG2*T400N)1Feah mice

abnormal heart left ventricle morphology ( J:123005 )

• mice exhibit increased left ventricular anterior wall thickness (LVAWT) compared with wild-type mice that is not as severe as in Tg(Myh6-PRKAG2*T400N)1Feah mice

• however, left ventricular end diastolic diameter is normal

decreased heart ventricle muscle contractility ( J:123005 )

• at 20 weeks, fractional shortening is reduced compared to in wild-type mice but not as severely as in Tg(Myh6-PRKAG2*T400N)1Feah mice

homeostasis/metabolism

increased cardiac muscle glycogen level ( J:123005 )

• myocytes exhibit increased glycogen content compared with wild-type cells that is not as severe as in myocytes from Tg(Myh6-PRKAG2*T400N)1Feah mice

muscle

increased cardiac muscle glycogen level ( J:123005 )

• myocytes exhibit increased glycogen content compared with wild-type cells that is not as severe as in myocytes from Tg(Myh6-PRKAG2*T400N)1Feah mice

decreased heart ventricle muscle contractility ( J:123005 )

• at 20 weeks, fractional shortening is reduced compared to in wild-type mice but not as severely as in Tg(Myh6-PRKAG2*T400N)1Feah mice

growth/size/body

increased heart weight ( J:123005 )

• mice exhibit increased heart weight compared with wild-type mice that is not as severe as in Tg(Myh6-PRKAG2*T400N)1Feah mice

Genotype
MGI:3639283

tg2

• Allelic Composition: Tg(Myh6-Prkaa2*D157A)1Rti/0
• Genetic Background: involves: FVB

cardiovascular system

abnormal response to cardiac infarction ( J:86014 )

• mutants exhibit normal cardiac morphology and physiology under normal conditions, however when subjected to ischemia, hearts show more rapid increase in left ventricular end-diastolic pressure, accelerated rate and extent of ATP depletion (increased ATP degradation), and a decrease in glucose uptake

homeostasis/metabolism

abnormal response to cardiac infarction ( J:86014 )

• mutants exhibit normal cardiac morphology and physiology under normal conditions, however when subjected to ischemia, hearts show more rapid increase in left ventricular end-diastolic pressure, accelerated rate and extent of ATP depletion (increased ATP degradation), and a decrease in glucose uptake