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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Malt1tm1Mak
targeted mutation 1, Tak Mak
MGI:3639305
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Malt1tm1Mak/Malt1tm1Mak involves: 129P2/OlaHsd MGI:3639741
cn2
 		Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld/Gt(ROSA)26Sor+
Malt1tm1Mak/Malt1tm1Mak 		involves: 129P2/OlaHsd MGI:5908455


Genotype
MGI:3639741
hm1
Allelic
Composition		 Malt1tm1Mak/Malt1tm1Mak
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Malt1tm1Mak mutation (1 available); any Malt1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell proliferation ( J:109545 )
• purified T lymphocytes fail to expand or produce Il2 when stimulated with antiCD3 +/- antiCD28 costimulation; they do not respond to stimulation with PMA
decreased IgG level ( J:109545 )
• immunization with keyhole limpet hemocyanin doe not induce any production of KLH-specific IgG in mutants compared to wild-type
• IgG3 responses against TNP-Ficoll are absent for at least 21 days
decreased IgM level ( J:109545 )
• immunization with keyhole limpet hemocyanin doe not induce any production of KLH-specific IgM in mutants compared to wild-type
• IgM responses against TNP-Ficoll are absent for at least 21 days
abnormal dendritic cell physiology ( J:111706 )
• impaired zymosan-induced production of Tnfa in bone marrow dendritic cells
• impaired fungal cell-induced production of Tnfa, Il2, and Il10 in bone marrow dendritic cells

hematopoietic system
decreased T cell proliferation ( J:109545 )
• purified T lymphocytes fail to expand or produce Il2 when stimulated with antiCD3 +/- antiCD28 costimulation; they do not respond to stimulation with PMA
decreased IgG level ( J:109545 )
• immunization with keyhole limpet hemocyanin doe not induce any production of KLH-specific IgG in mutants compared to wild-type
• IgG3 responses against TNP-Ficoll are absent for at least 21 days
decreased IgM level ( J:109545 )
• immunization with keyhole limpet hemocyanin doe not induce any production of KLH-specific IgM in mutants compared to wild-type
• IgM responses against TNP-Ficoll are absent for at least 21 days

cellular
decreased T cell proliferation ( J:109545 )
• purified T lymphocytes fail to expand or produce Il2 when stimulated with antiCD3 +/- antiCD28 costimulation; they do not respond to stimulation with PMA




Genotype
MGI:5908455
cn2
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld/Gt(ROSA)26Sor+
Malt1tm1Mak/Malt1tm1Mak
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Malt1tm1Mak mutation (1 available); any Malt1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:228288 )
N
• absence of Malt1 expression rescues the early lethality seen in mutant mice wild-type for Malt1

immune system
immune system phenotype ( J:228288 )
N
• absence of Malt1 expression rescues the pathological B-cell activation, differentiation, and malignant proliferation seen in mutant mice wild-type for Malt1




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory