All Phenotypes Cd4<tm1Jrp> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cd4^tm1Jrp
targeted mutation 1, Jane R Parnes
MGI:3639344

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd4^tm1Jrp/Cd4^tm1Jrp	either: B6.129S2-Cd4^tm1Jrp or B10.Cg-Cd4^tm1Jrp	MGI:3652733
cx2	Cd4^tm1Jrp/Cd4^tm1Jrp Tg(TcrAND)53Hed/0	either: (involves: 129S2/SvPas * C57BL/6 * SJL) or (involves: 129S2/SvPas * C57BL/6 * C57BL/10 * SJL)	MGI:3652735
cx3	B2m^tm1Jae/B2m^tm1Jae Cd4^tm1Jrp/Cd4^tm1Jrp	involves: 129S2/SvPas * C57BL/6	MGI:3652734

Allelic Composition	Cd4^tm1Jrp/Cd4^tm1Jrp
Genetic Background	either: B6.129S2-Cd4^tm1Jrp or B10.Cg-Cd4^tm1Jrp

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4^tm1Jrp mutation (0 available); any Cd4 mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:45168 )

• in single positive thymocytes and on splenic T cells, level of CD4 is 80% that in wild-type

decreased double-positive T cell number ( J:45168 )

• level of CD4 is 50% that in wild-type

decreased CD4-positive, alpha-beta T cell number ( J:45168 )

• reduction in CD4 compartment is 19.1%; there is a decrease in Cd4+ cells in thymus

increased CD8-positive, alpha-beta T cell number ( J:45168 )

• there is an increase of 67.1% in CD8+ cells in thymus

hematopoietic system

abnormal T cell differentiation ( J:45168 )

• in single positive thymocytes and on splenic T cells, level of CD4 is 80% that in wild-type

decreased double-positive T cell number ( J:45168 )

• level of CD4 is 50% that in wild-type

decreased CD4-positive, alpha-beta T cell number ( J:45168 )

• reduction in CD4 compartment is 19.1%; there is a decrease in Cd4+ cells in thymus

increased CD8-positive, alpha-beta T cell number ( J:45168 )

• there is an increase of 67.1% in CD8+ cells in thymus

Allelic Composition	Cd4^tm1Jrp/Cd4^tm1Jrp Tg(TcrAND)53Hed/0
Genetic Background	either: (involves: 129S2/SvPas * C57BL/6 * SJL) or (involves: 129S2/SvPas * C57BL/6 * C57BL/10 * SJL)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4^tm1Jrp mutation (0 available); any Cd4 mutation (85 available)
Tg(TcrAND)53Hed mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hyperplasia ( J:45168 )

• thymi have considerably greater cellularity (33-113% more cells) than littermates

abnormal T cell number ( J:45168 )

• mutant thymus has a 58% reduction in CD4+ thymocytes compared to littermates that only expressing the transgene

hematopoietic system

thymus hyperplasia ( J:45168 )

• thymi have considerably greater cellularity (33-113% more cells) than littermates

abnormal T cell number ( J:45168 )

• mutant thymus has a 58% reduction in CD4+ thymocytes compared to littermates that only expressing the transgene

endocrine/exocrine glands

thymus hyperplasia ( J:45168 )

• thymi have considerably greater cellularity (33-113% more cells) than littermates

Allelic Composition	B2m^tm1Jae/B2m^tm1Jae Cd4^tm1Jrp/Cd4^tm1Jrp
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2m^tm1Jae mutation (8 available); any B2m mutation (122 available)
Cd4^tm1Jrp mutation (0 available); any Cd4 mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased CD8-positive, alpha-beta T cell number ( J:45168 )

• an increase in CD8+ T cells similar to that seen in single Cd4^tm1Jrp mutants

immune system

increased CD8-positive, alpha-beta T cell number ( J:45168 )

• an increase in CD8+ T cells similar to that seen in single Cd4^tm1Jrp mutants

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