Phenotypes associated with this allele

• Allele Symbol: Cpt1c^tm1Mdln
• Allele Name: targeted mutation 1, M Daniel Lane
• Allele ID: MGI:3639356
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cpt1c^tm1Mdln/Cpt1c^tm1Mdln	involves: C57BL/6	MGI:3640082

Genotype
MGI:3640082

hm1

• Allelic Composition: Cpt1c^tm1Mdln/Cpt1c^tm1Mdln
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:109455 )

• at 12 weeks of age, homozygotes show a significant reduction (15%) in body weight; males tend to have less visceral fat

increased susceptibility to weight gain ( J:109455 )

• on a high-fat diet, null mice rapidly gain weight, are equivalent in weight to wild-type at week 5 and weigh more after 5 weeks

behavior/neurological

decreased food intake ( J:109455 )

• null animals show a 25% reduction in food intake over a 24 hour period compared to wild-type

homeostasis/metabolism

increased circulating triglyceride level ( J:109455 )

• male Cpt1c-deficient mice have significantly higher circulating triglyceride levels but are still in the normal range

hyperlipidemia ( J:109455 )

• null mice on a high-fat diet exhibit hyperlipidemia

insulin resistance ( J:109455 )

• at 17 weeks, null mice exhibit prolonged and increased glucose clearance with an increase in plasma insulin, indicating mild insulin resistance

liver/biliary system

hepatic steatosis ( J:109455 )

• at necropsy, hepatic steatosis is found in animals on a high-fat diet