Phenotypes associated with this allele

• Allele Symbol: Tg(Mt1a-GPHB5)1Sok
• Allele Name: transgene insertion 1, Shannon L Okada
• Allele ID: MGI:3639358
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Mt1a-GPHB5)1Sok/0	involves: C57BL/6	MGI:3639429

Genotype
MGI:3639429

tg1

• Allelic Composition: Tg(Mt1a-GPHB5)1Sok/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:105176 )

• male and female transgenic mice have significantly reduced body weights compared to controls at 6 weeks of age (transgenics: M 23.3 g, F 17.8g vs controls: M 29.6g, F 23.7g)

homeostasis/metabolism

increased circulating thyroxine level ( J:105176 )

• serum T₄ levels are 2- to 3-fold above those of littermates

endocrine/exocrine glands

abnormal adrenal cortex morphology ( J:105176 )

• hypertrophy of cell in the inner adrenal cortex is observed in transgenic mice

abnormal thyroid follicle morphology ( J:105176 )

• glands show hypertrophy of the thyroid follicles in transgenic mice but not in littermate controls

abnormal thyroid follicular cell morphology ( J:105176 )

• hyperplasia of the thyroid follicular epithelial cells in transgenic mice but not in littermate controls

vision/eye

exophthalmos ( J:105176 )

• animals develop bulging eyes