Analysis Tools
mortality/aging
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• many mutants die by 100 days of age of heart failure
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cardiovascular system
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• at the time of death, heart weight relative to body weight is increased; degree of cardiomegaly is less than in transgenic line O7 but more than in line J3
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• increase in left ventricular mass developing at 3 weeks of age and progressively increasing over time
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• wall thickness is increased at 3 weeks of age but subsequently decreased below controls
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• exhibit normal fractional shortening at 2 and 3 weeks of age but marked deterioration of systolic performance from 4 weeks onward
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• seen from 4 weeks of age onward
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muscle
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• increase in left ventricular mass developing at 3 weeks of age and progressively increasing over time
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• exhibit normal fractional shortening at 2 and 3 weeks of age but marked deterioration of systolic performance from 4 weeks onward
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growth/size/body
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• at the time of death, heart weight relative to body weight is increased; degree of cardiomegaly is less than in transgenic line O7 but more than in line J3
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• increase in left ventricular mass developing at 3 weeks of age and progressively increasing over time
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