Phenotypes associated with this allele

• Allele Symbol: Ddr2^slie
• Allele Name: smallie
• Allele ID: MGI:3640081
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ddr2^slie/Ddr2^slie	BKSChpLt.Cg-Tg(Ins2-Cpe)1Lt Cpe^fat/LtJng	MGI:3785750

Genotype
MGI:3785750

hm1

• Allelic Composition: Ddr2^slie/Ddr2^slie
• Genetic Background: BKSChpLt.Cg-Tg(Ins2-Cpe)1Lt Cpe^fat/LtJng

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:134371 )

• 15% of homozygotes die before 3 months of age and 47% die by 6 months

endocrine/exocrine glands

small pituitary gland ( J:134371 )

• proportion of pituitary gland area to whole brain area is reduced as compared to wild-type at 4 weeks, however, size difference disappears by adulthood

absent corpus luteum ( J:134371 )

♀ • corpora lutea is absent in 6 week old and 4 month old females, however, pre-antral, antral and Graffian follicles appear normal

abnormal Sertoli cell morphology ( J:134371 )

♂ • atrophy is observed in Sertoli cells at 4 months

Leydig cell atrophy ( J:134371 )

♂ • atrophy is observed in Leydig cells at 4 months

growth/size/body

short snout ( J:134371 )

• snub nose is visible by four months of age

increased lean body mass ( J:134371 )

• significant increase in percentage of lean mass at 5-6 months as compared to wild-type

slow postnatal weight gain ( J:134371 )

• after weaning weight gain is slower than in wild-type

• homozygotes do not exhibit juvenile growth spurt

disproportionate dwarf ( J:134371 )

adipose tissue

decreased percent body fat/body weight ( J:134371 )

• significant decrease in percentage of body fat at 5-6 months as compared to wild-type

craniofacial

short snout ( J:134371 )

• snub nose is visible by four months of age

homeostasis/metabolism

decreased blood urea nitrogen level ( J:134371 )

increased circulating glucose level ( J:134371 )

decreased circulating testosterone level ( J:134371 )

• following injection of exogenous gonadotropin in 12-14 week old mice, testosterone levels are lower than adult wild-type and similar to prepubertal wild-type

decreased circulating estradiol level ( J:134371 )

• following injection of exogenous gonadotropin in 12-14 week old mice, estradiol levels are lower than adult wild-type and similar to prepubertal wild-type

decreased circulating progesterone level ( J:134371 )

• following injection of exogenous gonadotropin in 12-14 week old mice, progesterone levels are lower than adult wild-type and similar to prepubertal wild-type

vision/eye

exophthalmos ( J:134371 )

• protuberant eyes are observed by four months of age

skeleton

decreased bone mineral content ( J:134371 )

• bone mineral content is reduced in comparison to wild-type, however density is not reduced

reproductive system

abnormal spermatid morphology ( J:134371 )

♂ • number of spermatids is reduced in 4 month old mice, but not in 6 week old mice

abnormal spermatogonia morphology ( J:134371 )

♂ • atrophy is observed in spermatogonia at 4 months

absent corpus luteum ( J:134371 )

♀ • corpora lutea is absent in 6 week old and 4 month old females, however, pre-antral, antral and Graffian follicles appear normal

abnormal Sertoli cell morphology ( J:134371 )

♂ • atrophy is observed in Sertoli cells at 4 months

Leydig cell atrophy ( J:134371 )

♂ • atrophy is observed in Leydig cells at 4 months

abnormal vagina orifice morphology ( J:134371 )

♀ • following injection of exogenous gonadotropin in 12-14 week old mice, vaginal opening is observed in 100% of prepubertal wild-type and 80% of adult homozygotes, however, the condition is pre-existing in wild-type 12-14 week old mice

anovulation ( J:134371 )

♀ • females are anovulatory

failure of superovulation ( J:134371 )

♀ • following injection of PMSG and hCG at 6 weeks follicular growth to the Graffian stage is induced, but full luteinization of thecal cells does not occur and no corpora lutea are formed

female infertility ( J:134371 )

♀ • female homozygote matings to wild-type males fail to produce offspring

reduced male fertility ( J:134371 )

♂ • occasionally homozygote males crossed to heterozygote or wild-type females produce offspring

nervous system

small pituitary gland ( J:134371 )

• proportion of pituitary gland area to whole brain area is reduced as compared to wild-type at 4 weeks, however, size difference disappears by adulthood

cellular

abnormal spermatid morphology ( J:134371 )

♂ • number of spermatids is reduced in 4 month old mice, but not in 6 week old mice

abnormal spermatogonia morphology ( J:134371 )

♂ • atrophy is observed in spermatogonia at 4 months