Phenotypes associated with this allele

• Allele Symbol: Gnmt^tm1Cwa
• Allele Name: targeted mutation 1, Conrad Wagner
• Allele ID: MGI:3640328
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gnmt^tm1Cwa/Gnmt^tm1Cwa	involves: 129 * C57BL/6J	MGI:3640329

Genotype
MGI:3640329

hm1

• Allelic Composition: Gnmt^tm1Cwa/Gnmt^tm1Cwa
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal amino acid level ( J:110257 )

• free methionine are increased to 700 nmol/g liver and S-adenosylmethionine levels are increased to 1334 nmol/g liver compared to 100 and 37 nmol/g liver, respectively, in wild-type mice

• the ratio of S-adenosylmethionine to S-adenosylhomocysteine is increased about 100 fold

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
glycine N-methyltransferase deficiency		DOID:0111037	OMIM:606664	J:110257