Phenotypes associated with this allele

• Allele Symbol: Hmgcl^tm1Gam
• Allele Name: targeted mutation 1, Grant A Mitchell
• Allele ID: MGI:3640351
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hmgcl^tm1Gam/Hmgcl^tm1Gam	either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)	MGI:3640619
ht2	Hmgcl^tm1Gam/Hmgcl^+	either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)	MGI:3640620

Genotype
MGI:3640619

hm1

• Allelic Composition: Hmgcl^tm1Gam/Hmgcl^tm1Gam
• Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:52117 )

• the expected numbers of embryos are found at E10.5 and E11.5 but by E12.5 and E13.5 only 1 embryo is present

liver/biliary system

abnormal hepatocyte morphology ( J:52117 )

• moderate to marked vacuolization is seen at E11.5 particularly in mitochondria

abnormal hepatocyte mitochondrial morphology ( J:52117 )

cardiovascular system

abnormal heart morphology ( J:52117 )

• vacuoles are frequently seen at E11.5

embryo

decreased embryo size ( J:52117 )

• at E10.5 and E11.5

abnormal placenta morphology ( J:52117 )

• vacuoles are frequently seen at E11.5

growth/size/body

decreased embryo size ( J:52117 )

• at E10.5 and E11.5

cellular

abnormal hepatocyte mitochondrial morphology ( J:52117 )

Genotype
MGI:3640620

ht2

• Allelic Composition: Hmgcl^tm1Gam/Hmgcl⁺
• Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)

liver/biliary system

abnormal hepatocyte morphology ( J:52117 )

• focal and mild vacuolization is seen at E11.5 in 2 of 8 embryos but is not seen in wild-type embryos