Phenotypes associated with this allele

• Allele Symbol: Hoxc^tm1Nogu
• Allele Name: targeted mutation 1, Shigeru Noguchi
• Allele ID: MGI:3640654
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxc^tm1Nogu/Hoxc^tm1Nogu	involves: 129S/SvEv * C57BL/6	MGI:5286745

Genotype
MGI:5286745

hm1

• Allelic Composition: Hoxc^tm1Nogu/Hoxc^tm1Nogu
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:61710 )

• homozygous pups are found dead in the cage on the day of birth and display no signs of feeding; when removed by caesarian section on E19, homozygotes are alive and indistinguishable from littermates, but could not breathe and die within 10 minutes

skeleton

abnormal rib morphology ( J:61710 )

• the tips of the floating ribs are rounded in mutants compared to wild-type

abnormal vertebrae morphology ( J:61710 )

• neural arch of the tenth thoracic to first lumbar vertebrae is square shaped

abnormal caudal vertebrae morphology ( J:61710 )

• mutant mice have first to ninth/eleventh caudal vertebrae with lateral projections

caudal vertebral transformation ( J:61710 )

• the first caudal vertebra is transformed anteriorly at one segment into a lumbar vertebra

abnormal thoracic vertebrae morphology ( J:61710 )

• thoracic vertebrae anterior to thoracic vertebra 12 have transverse processes with processes of the twelfth being smaller than the others

• the spinus process of the second thoracic vertebra is smaller than in wild-type

thoracic vertebral transformation ( J:61710 )

• the second lumbar vertebra resembles the transitional vertebra resulting in the anterior transformation of neural arches from T10-L2

• anterior transformation of transverse process is observed only in thoracic vertebrae 10-12 but not in 13 to lumbar vertebrae 2

lumbar vertebral transformation ( J:61710 )

• mutants display anterior transformation of the lumbar vertebrae 1 and 2 but have the normal number of vertebra bearing ribs

sacral vertebral transformation ( J:61710 )

• 70% of null mice show anterior transformation of the first sacral vetebra to an additional lumbar vertebra, but had the normal number of sacral vertebrae

respiratory system

abnormal pulmonary alveolus morphology ( J:61710 )

• at time of death, alveoli are shrunken and lungs contain little air

limbs/digits/tail

abnormal caudal vertebrae morphology ( J:61710 )

• mutant mice have first to ninth/eleventh caudal vertebrae with lateral projections

caudal vertebral transformation ( J:61710 )

• the first caudal vertebra is transformed anteriorly at one segment into a lumbar vertebra

integument

absent vibrissae ( J:61710 )

• homozygotes lack vibrissae in the face