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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Myh6-EP300)21Csk
transgene insertion 21, Chugai Pharmaceutical Co, Ltd
MGI:3640671
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Myh6-EP300)21Csk/0 C57BL/6-Tg(Myh6-EP300)21Csk MGI:3690081


Genotype
MGI:3690081
tg1
Allelic
Composition
Tg(Myh6-EP300)21Csk/0
Genetic
Background
C57BL/6-Tg(Myh6-EP300)21Csk
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants treated with doxorubicin, an anti-tumor agent with cardiotoxicity, show a higher survival rate
• mutants are prone to premature death after 20 weeks of age and show lower survival rates than wild-type at 42 weeks of age

cardiovascular system
• hearts show hypertrophy of individual myocytes but no evidence of increased fibrosis, myofibrillar disarray, or inflammatory changes
• cross-sectional myocardial-cell diameter is increased
• hearts show an increase in heart weight-to-body weight ratio
• show dilatation of the left ventricles without a significant increase in wall thickness at 24 weeks of age
• at 24 weeks of age, show depressed fractional shortening and increased cavity diameter of the left ventricles but no differences in left ventricular wall thickness and heart rate
• develop heart failure after 20 weeks of age

muscle
• hearts show hypertrophy of individual myocytes but no evidence of increased fibrosis, myofibrillar disarray, or inflammatory changes
• cross-sectional myocardial-cell diameter is increased
• at 24 weeks of age, show depressed fractional shortening and increased cavity diameter of the left ventricles but no differences in left ventricular wall thickness and heart rate

homeostasis/metabolism
• mutants treated with doxorubicin, an anti-tumor agent with cardiotoxicity, show a higher survival rate
• mutants treated with doxorubicin, an anti-tumor agent with cardiotoxicity, show more preserved left ventricular function, and no myocardial cell apoptosis compared to wild-type, indicating prevention of acute heart failure

growth/size/body
• hearts show an increase in heart weight-to-body weight ratio





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory