Phenotypes associated with this allele

• Allele Symbol: Gucy1a1^tm1.1Dko
• Allele Name: targeted mutation 1.1, Doris Koesling
• Allele ID: MGI:3640804
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gucy1a1^tm1.1Dko/Gucy1a1^tm1.1Dko	involves: C57BL/6	MGI:3640807

Genotype
MGI:3640807

hm1

• Allelic Composition: Gucy1a1^tm1.1Dko/Gucy1a1^tm1.1Dko
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased systemic arterial systolic blood pressure ( J:110362 )

• systolic blood pressure is 111 +/- 2 mmHg compared to 104 +/- 2 mmHg in wild-type

abnormal vasodilation ( J:110362 )

• the dose-response curve for NO-induced relaxation of aortic rings is shifted to the right and the EC50 is increased about 5-fold

• carbachol (30 uM) induces only about 50% relaxation of aortic rings compared to wild-type where this concentration induces almost complete relaxation

hematopoietic system

abnormal platelet aggregation ( J:110362 )

• NO-induced inhibition of collagen-induced aggregation is absent

homeostasis/metabolism

abnormal platelet aggregation ( J:110362 )

• NO-induced inhibition of collagen-induced aggregation is absent

muscle

abnormal vasodilation ( J:110362 )

• the dose-response curve for NO-induced relaxation of aortic rings is shifted to the right and the EC50 is increased about 5-fold

• carbachol (30 uM) induces only about 50% relaxation of aortic rings compared to wild-type where this concentration induces almost complete relaxation