All Phenotypes Ntrk2<tm1.1Tes> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ntrk2^tm1.1Tes
targeted mutation 1.1, Lino Tessarollo
MGI:3640817

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ntrk2^tm1.1Tes/Ntrk2^tm1.1Tes	B6.129S1-Ntrk2^tm1.1Tes	MGI:3833378
hm2	Ntrk2^tm1.1Tes/Ntrk2^tm1.1Tes	involves: 129S1/Sv	MGI:5617022
ht3	Ntrk2^tm1.1Tes/Ntrk2⁺	B6.129S1-Ntrk2^tm1.1Tes	MGI:3833379
cx4	Bdnf^tm1Par/Bdnf⁺ Ntrk2^tm1.1Tes/Ntrk2^tm1.1Tes	B6.129S1-Bdnf^tm1Par Ntrk2^tm1.1Tes	MGI:3833380
cx5	Bdnf^tm1Par/Bdnf⁺ Ntrk2^tm1.1Tes/Ntrk2⁺	B6.129S1-Bdnf^tm1Par Ntrk2^tm1.1Tes	MGI:3833382
cx6	Ntrk2^tm1.1Tes/Ntrk2⁺ Rb(12.Ts17¹⁶65Dn)2Cje/0	involves: 129S1/Sv * C3H/HeSnJ * C57BL/6JEi	MGI:3833368

Allelic Composition	Ntrk2^tm1.1Tes/Ntrk2^tm1.1Tes
Genetic Background	B6.129S1-Ntrk2^tm1.1Tes

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk2^tm1.1Tes mutation (0 available); any Ntrk2 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased thigmotaxis ( J:144845 )

• mice spend less time and make fewer entries into the middle of an open field test

• mice spend less than a third of the time as controls in the open arms of elevated plus maze test

nervous system

abnormal amygdala morphology ( J:144845 )

• there is a decrease in dendritic arbor complexity at 90 micrometers and greater distances from the soma for neurons within the amygdale

• there is also a decrease in dendritic length for these neurons

abnormal dendrite morphology ( J:144845 )

• there is a decrease in dendritic arbor complexity at 90 micrometers and greater distances from the soma for neurons within the amygdale

• there is also a decrease in dendritic length for these neurons

Allelic Composition	Ntrk2^tm1.1Tes/Ntrk2^tm1.1Tes
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk2^tm1.1Tes mutation (0 available); any Ntrk2 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal mammary gland sensory innervation pattern ( J:192549 )

• at E13, male mice exhibit increased sensory neurons innervating the mammary gland compared with wild-type mice

• however, female mice exhibit normal mammary gland innervation

endocrine/exocrine glands

abnormal mammary gland sensory innervation pattern ( J:192549 )

• at E13, male mice exhibit increased sensory neurons innervating the mammary gland compared with wild-type mice

• however, female mice exhibit normal mammary gland innervation

integument

abnormal mammary gland sensory innervation pattern ( J:192549 )

• at E13, male mice exhibit increased sensory neurons innervating the mammary gland compared with wild-type mice

• however, female mice exhibit normal mammary gland innervation

Allelic Composition	Ntrk2^tm1.1Tes/Ntrk2⁺
Genetic Background	B6.129S1-Ntrk2^tm1.1Tes

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk2^tm1.1Tes mutation (0 available); any Ntrk2 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased thigmotaxis ( J:144845 )

• mice spend less time and make fewer entries into the middle of an open field test

• mice spend less than two-thirds of the time as controls in the open arms of elevated plus maze test

Allelic Composition	Bdnf^tm1Par/Bdnf⁺ Ntrk2^tm1.1Tes/Ntrk2^tm1.1Tes
Genetic Background	B6.129S1-Bdnf^tm1Par Ntrk2^tm1.1Tes

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Par mutation (0 available); any Bdnf mutation (42 available)
Ntrk2^tm1.1Tes mutation (0 available); any Ntrk2 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased aggression towards male mice ( J:144845 )

• male mice have decreased latency time to first biting attack against intruder males compared to wild-type controls

• male mice also have a significantly increased number of biting attacks over a 5 minute period

• the latency time and number of attacks are not to the same degree as mice that only carry the Bdnf^tm1Par mutant allele

growth/size/body

increased body weight ( J:144845 )

• mice gain weight with age though not to the degree as mice that only carry the Bdnf^tm1Par mutant allele

Allelic Composition	Bdnf^tm1Par/Bdnf⁺ Ntrk2^tm1.1Tes/Ntrk2⁺
Genetic Background	B6.129S1-Bdnf^tm1Par Ntrk2^tm1.1Tes

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased aggression towards male mice ( J:144845 )

• male mice have decreased latency time to first biting attack against intruder males compared to wild-type controls

• male mice also have a significantly increased number of biting attacks over a 5 minute period

• the latency time and number of attacks are not to the same degree as mice that only carry the Bdnf^tm1Par mutant allele

Allelic Composition	Ntrk2^tm1.1Tes/Ntrk2⁺ Rb(12.Ts17¹⁶65Dn)2Cje/0
Genetic Background	involves: 129S1/Sv * C3H/HeSnJ * C57BL/6JEi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk2^tm1.1Tes mutation (0 available); any Ntrk2 mutation (66 available)
Rb(12.Ts17¹⁶65Dn)2Cje mutation (1 available); any Rb(12.Ts17¹⁶65Dn)2Cje mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:110478 )

N	• the Ntrk2^tm1.1Tes allele rescues the increased apoptosis of cortical cells in vivo, and the accelerated death of hippocampal neurons in vitro that occurs with cells carrying the Rb(12.Ts171665Dn)2Cje allele

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