Analysis Tools
mortality/aging
|
• die between E9.5 and E10.5
|
embryo
|
• at E9.5 yolk sacs lack an organized vasculature and instead have blood filled patched cavities surrounded by endothelial cells
|
|
• about 85% fail to initiate turning by E9.5
|
|
• at E9.5
|
|
• at E9.5
|
|
• kinked and undulated along the entire length at E8.5
|
|
• kinked and undulated along the entire length at E8.5
|
|
• embryos with failure of chorioallantoic fusion also have a swollen allantois
|
|
• failure of fusion in about 40%
|
cardiovascular system
|
• at E9.5 vessels appear enlarged especially in the head region; however, embryos are not hemorrhagic and cardiac development appears grossly normal
|
|
• at E9.5 yolk sacs lack an organized vasculature and instead have blood filled patched cavities surrounded by endothelial cells
|
homeostasis/metabolism
|
• at E8.5 effusions are seen in the head region and along the dorsal side of the embryo in 83% and 44% of embryos, respectively
|
nervous system
|
• at E9.5
|
|
• kinked and undulated along the entire length at E8.5
|
|
• kinked and undulated along the entire length at E8.5
|
|
• at E8.5 in more than 80% of embryos asymmetric enlargement of the neural headfolds is seen with the enlarged fold containing large cavities or effusions
|
growth/size/body
|
• at E9.5
|
