Phenotypes associated with this allele

• Allele Symbol: Acaca^tm2Sjw
• Allele Name: targeted mutation 2, Salih J Wakil
• Allele ID: MGI:3641125
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Acaca^tm2Sjw/Acaca^tm2Sjw Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129S7/SvEvBrd * C57BL/6J * FVB	MGI:3641135

Genotype
MGI:3641135

cn1

• Allelic Composition: Acaca^tm2Sjw/Acaca^tm2Sjw; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

decreased liver triglyceride level ( J:110200 )

• on a normal diet liver levels are about 40% lower than in wild-type

decreased susceptibility to hepatic steatosis ( J:110200 )

• after being on a fat free diet for 10 days lipid accumulation in the liver is 66% lower than in wild-type; however fat pad weight is similar to wild-type

• however, when fed a high fat high carbohydrate diet fatty liver development is similar to wild-type

abnormal liver physiology ( J:110200 )

• in cultured hepatocytes the rate of fatty acid synthesis is about 50% of wild-type

• liver acetyl-CoA carboxylase activity is reduced by about 75%

homeostasis/metabolism

decreased circulating ketone body level ( J:110200 )

• on a high fat high carbohydrate but not on a standard chow diet

abnormal glucose homeostasis ( J:110200 )

hyperglycemia ( J:110200 )

• on a high fat high carbohydrate diet blood glucose is increased to 185 +/- 7 mg/dl compared to 155 +/-8 mg/dl for wild-type mice

• however, on a standard diet blood glucose levels are similar

increased circulating insulin level ( J:110200 )

• after being on a fat free diet for 10 days insulin levels are increased but blood glucose is similar to wild-type

abnormal lipid level ( J:110200 )

increased circulating free fatty acids level ( J:110200 )

• on a high fat high carbohydrate nonesterified fatty acid levels are increased by about 30% compared to wild-type mice

decreased fatty acids level ( J:110200 )

• after being on a fat free diet for 10 days liver levels of saturated and monounsaturated fatty acids are significantly lower than in wild-type; however overall liver lipid composition is similar

decreased circulating free fatty acids level ( J:110200 )

• on a normal diet or when fed a fat free diet for 10 days

decreased liver triglyceride level ( J:110200 )

• on a normal diet liver levels are about 40% lower than in wild-type

abnormal enzyme/coenzyme activity ( J:110200 )

• liver acetyl-CoA carboxylase activity is reduced by about 75%