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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sh2d1b2tm1Vei
targeted mutation 1, Andre Veillette
MGI:3641175
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sh2d1b2tm1Vei/Sh2d1b2tm1Vei involves: 129S1/Sv * 129X1/SvJ MGI:3641455
cx2
 		Sh2d1b1tm2Vei/Sh2d1b1tm2Vei
Sh2d1b2tm1Vei/Sh2d1b2tm1Vei 		involves: 129S1/Sv * 129X1/SvJ MGI:3836742


Genotype
MGI:3641455
hm1
Allelic
Composition		 Sh2d1b2tm1Vei/Sh2d1b2tm1Vei
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1b2tm1Vei mutation (0 available); any Sh2d1b2 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired natural killer cell mediated cytotoxicity ( J:145969 )
• mutant NK cells lack enhanced lysis of target cells expressing Slamf7 (CRACC)
• NK cell have inhibited killing of B16 melonama cells expressing CRACC
increased natural killer cell mediated cytotoxicity ( J:110195 )
• Il2-activated NK cells have an increased ability to kill target cells like YB cells in vitro

hematopoietic system
impaired natural killer cell mediated cytotoxicity ( J:145969 )
• mutant NK cells lack enhanced lysis of target cells expressing Slamf7 (CRACC)
• NK cell have inhibited killing of B16 melonama cells expressing CRACC
increased natural killer cell mediated cytotoxicity ( J:110195 )
• Il2-activated NK cells have an increased ability to kill target cells like YB cells in vitro




Genotype
MGI:3836742
cx2
Allelic
Composition		 Sh2d1b1tm2Vei/Sh2d1b1tm2Vei
Sh2d1b2tm1Vei/Sh2d1b2tm1Vei
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1b1tm2Vei mutation (0 available); any Sh2d1b1 mutation (11 available)
Sh2d1b2tm1Vei mutation (0 available); any Sh2d1b2 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired natural killer cell mediated cytotoxicity ( J:145969 )
• mutant NK cells lack enhanced lysis of target cells expressing Slamf7 (CRACC)
• NK cell are inhibited from killing B16 melonama cells expressing CRACC

hematopoietic system
impaired natural killer cell mediated cytotoxicity ( J:145969 )
• mutant NK cells lack enhanced lysis of target cells expressing Slamf7 (CRACC)
• NK cell are inhibited from killing B16 melonama cells expressing CRACC




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory